scholarly journals Downregulation of cyclooxygenase‑1 stimulates mitochondrial apoptosis through the NF‑κB signaling pathway in colorectal cancer cells

2018 ◽  
Author(s):  
Lei Ding ◽  
Huan Gu ◽  
Zhenwei Lan ◽  
Qingchun Lei ◽  
Wenxue Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mitochondrial Apoptosis ◽  
Cyclooxygenase 1 ◽  
Colorectal Cancer Cells

scholarly journals Curcumol inhibits the viability and invasion of colorectal cancer cells via miR‑30a‑5p and Hippo signaling pathway

2021 ◽  
Vol 21 (4) ◽  
Author(s):  
Dan Yu ◽  
Haiping Liu ◽  
Jianli Qin ◽  
Mengjie Huangfu ◽  
Xiao Guan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hippo Signaling ◽  
Hippo Signaling Pathway ◽  
Colorectal Cancer Cells

scholarly journals circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway

2021 ◽  
Vol 12 (6) ◽  
pp. 1678-1686
Author(s):  
Wei Zhang ◽  
Gang Wu ◽  
Peichun Sun ◽  
Yuanzeng Zhu ◽  
Han Zhang
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colorectal Cancer Cells

LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/β-catenin signaling pathway in colorectal cancer cells

2014 ◽  
Vol 26 (11) ◽  
pp. 2333-2342 ◽  
Author(s):  
Hung-Chih Hsu ◽  
Yi-Shiuan Liu ◽  
Kai-Chi Tseng ◽  
Bertrand Chin-Ming Tan ◽  
Shu-Jen Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colorectal Cancer Cells

scholarly journals Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Wanjuan Xue ◽  
Yongcheng Liu ◽  
Ningning Xin ◽  
Jiyu Miao ◽  
Juan Du ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Colon ◽  
Caspase 9 ◽  
Human Colon Cancer ◽  
Expression Levels ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

The study is aimed at investigating the role of Nei endonuclease VIII-like1 (NEIL1) in the pathogenesis of colorectal cancer (CRC). The human CRC (HCT116 and SW480) cells were subjected to the siRNA silencing and recombinant plasmid overexpression of NEIL1. Transfection of siNEIL1 significantly inhibited the cell growth. It also increased the Bax expression levels, while it decreased the Bcl-2 expression levels in human CRC cells, leading the Bax/Bcl-2 balance toward apoptosis. Moreover, the apoptosis was promoted through the caspase-9 signaling pathway. One the other hand, high expression of NEIL1 promoted the cell viability and reduced the apoptosis, inducing the balance of Bax/Bcl-2 in the human colon cancer cells to be antiapoptotic. In addition, the caspase-9 signaling pathway inhibited apoptosis, contrary to the results obtained by downregulating NEIL1 expression. Furthermore, NEIL1 was negatively regulated by miR-7-5p, indicating that miR-7-5p inhibited the NEIL1 expression after transcription. Overexpression of miR-7-5p reversed the effects of NEIL1 on these CRC cells. In conclusion, NEIL1 promotes the proliferation of CRC cells, which is regulated negatively by miR-7-5p. These findings suggest that NEIL1 is a potential therapeutic target for CRC.

scholarly journals PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhao Yang ◽  
Shengwu Liu ◽  
Mingao Zhu ◽  
Hong Zhang ◽  
Ji Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colorectal Cancer Cells

scholarly journals GNA13 promotes tumor growth and angiogenesis by upregulating CXC chemokines via the NF-κB signaling pathway in colorectal cancer cells

2018 ◽  
Vol 7 (11) ◽  
pp. 5611-5620 ◽  
Author(s):  
Zhongqiang Zhang ◽  
Xiao Tan ◽  
Jing Luo ◽  
Beibei Cui ◽  
Sanlin Lei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colorectal Cancer Cells

scholarly journals The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Somrudee Reabroi ◽  
Rungnapha Saeeng ◽  
Nittaya Boonmuen ◽  
Teerapich Kasemsuk ◽  
Witchuda Saengsawang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Anti Cancer ◽  
Colorectal Cancer Cells ◽  
Gsk 3Β ◽  
Cancer Activity
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