scholarly journals Circadian clock gene Per2 downregulation in non‑small cell lung cancer is associated with tumour progression and metastasis

2018 ◽  
Author(s):  
Run Xiang ◽  
Yue Cui ◽  
Yanping Wang ◽  
Tianpeng Xie ◽  
Xiaojun Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Circadian Clock ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Clock Gene ◽  
Tumour Progression ◽  
Small Cell ◽  
Small Cell Lung ◽  
Circadian Clock Gene

scholarly journals Beneficial role of overexpression of TFPI-2 on tumour progression in human small cell lung cancer

FEBS Open Bio ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. 291-301 ◽  
Author(s):  
Marion Lavergne ◽  
Marie-Lise Jourdan ◽  
Claire Blechet ◽  
Serge Guyetant ◽  
Alain Le Pape ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumour Progression ◽  
Small Cell ◽  
Small Cell Lung ◽  
Beneficial Role

scholarly journals Expression of concern: Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression

Open Biology ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 200151
Author(s):  
Hongxu Liu ◽  
Yegang Ma ◽  
Changhao Liu ◽  
Pengfei Li ◽  
Tao Yu
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumour Progression ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Reduced miR-125a-5p level in non-small-cell lung cancer is associated with tumour progression

Open Biology ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 180118 ◽  
Author(s):  
Hongxu Liu ◽  
Yegang Ma ◽  
Changhao Liu ◽  
Pengfei Li ◽  
Tao Yu
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Progression ◽  
Cell Lung Cancer ◽  
Cpg Island ◽  
Tumour Progression ◽  
Small Cell ◽  
Small Cell Lung ◽  
Low Expression

Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumourigenesis and development. Although the low expression of miR-125a-5p in non-small-cell lung cancer (NSCLC) has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in NSCLC was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the CpG island in the miR-125a-5p region was hypermethylated in the tumour tissues, and the hypermethylation was negatively correlated with miR-125a-5p expression. Target gene screening showed that the histone methyltransferase Suv39H1 was one of the potential target genes. In vitro studies showed that miR-125a-5p could directly suppress Suv39H1 expression and decrease the H3K9me3 levels. On the other hand, Suv39H1 could induce demethylation of miR-125a-5p, resulting in re-activation of miR-125a-5p. What is more, overexpessing miR-125a-5p could also self-activate the silenced miR-125a-5p in NSCLC cells, which suppressed cell migration, invasion and proliferation in vitro and inhibited cancer progression in vivo . Thus, we found that the epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in NSCLC, suggesting that miR-125a-5p might not only have the potential prognostic value as a tumour biomarker but also be a potential therapeutic target in NSCLC.

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