scholarly journals C‑C chemokine receptor type�2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer

2018 ◽  
Author(s):  
Huijin Li ◽  
Hui Li ◽  
Xiao‑Peng Li ◽  
Haojun Zou ◽  
Liting Liu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Matrix Metalloproteinase ◽  
Chemokine Receptor ◽  
Human Liver ◽  
Epithelial To Mesenchymal Transition ◽  
Receptor Type ◽  
Matrix Metalloproteinase 2 ◽  
Mesenchymal Transition ◽  
Human Liver Cancer

scholarly journals Transcription factor SPZ1 promotes TWIST-mediated epithelial–mesenchymal transition and oncogenesis in human liver cancer

Oncogene ◽  
2017 ◽  
Vol 36 (31) ◽  
pp. 4405-4414 ◽  
Author(s):  
L-T Wang ◽  
S-S Chiou ◽  
C-Y Chai ◽  
E Hsi ◽  
C-M Chiang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Liver Cancer ◽  
Human Liver ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Human Liver Cancer

scholarly journals HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura Pelletier ◽  
Sandra Rebouissou ◽  
Danijela Vignjevic ◽  
Paulette Bioulac-Sage ◽  
Jessica Zucman-Rossi
Keyword(s):  
Liver Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Liver ◽  
Epithelial Mesenchymal Transition ◽  
Cancer Cell Lines ◽  
Liver Cancer Cell ◽  
Mesenchymal Transition ◽  
Human Liver Cancer Cell ◽  
Human Liver Cancer

scholarly journals Matrix Metalloproteinase 2-Integrin αvβ3 Binding Is Required for Mesenchymal Cell Invasive Activity but Not Epithelial Locomotion: A Computational Time-Lapse Study

2008 ◽  
Vol 19 (12) ◽  
pp. 5529-5540 ◽  
Author(s):  
Paul A. Rupp ◽  
Richard P. Visconti ◽  
András Czirók ◽  
David A. Cheresh ◽  
Charles D. Little
Keyword(s):  
Matrix Metalloproteinase ◽  
Epithelial To Mesenchymal Transition ◽  
Integrin Αvβ3 ◽  
Mesenchymal Cell ◽  
Time Lapse ◽  
Matrix Metalloproteinase 2 ◽  
Computational Time ◽  
Collagen Gels ◽  
Mesenchymal Transition ◽  
Invasive Behavior

Cellular invasive behavior through three-dimensional collagen gels was analyzed using computational time-lapse imaging. A subpopulation of endocardial cells, derived from explanted quail cardiac cushions, undergoes an epithelial-to-mesenchymal transition and invades the substance of the collagen gels when placed in culture. In contrast, other endocardial cells remain epithelial and move over the gel surface. Here, we show that integrin αvβ3 and matrix metalloproteinase (MMP)2 are present and active in cushion mesenchymal tissue. More importantly, functional assays show that mesenchymal invasive behavior is dependent on MMP2 activity and integrin αvβ3 binding. Inhibitors of MMP enzymatic activity and molecules that prevent integrin αvβ3 binding to MMP2, via its hemopexin domain, result in significantly reduced cellular protrusive activity and invasive behavior. Computational analyses show diminished intensity and persistence time of motility in treated invasive mesenchymal cells, but no reduction in motility of the epithelial-like cells moving over the gel surface. Thus, quantitative time-lapse data show that mesenchymal cell invasive behavior, but not epithelial cell locomotion over the gel surface, is partially regulated by the MMP2–integrin interactions.

scholarly journals EZH2-mediated epigenetic silencing of ZIC4 in hepatocellular carcinoma

2020 ◽  
Author(s):  
Jinghui Wang ◽  
Zhu Yang ◽  
Fengxi Long ◽  
Li Luo ◽  
Gao Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Human Liver ◽  
Antitumor Effect ◽  
Epithelial Mesenchymal Transition ◽  
Epigenetic Silencing ◽  
The Cancer Genome Atlas ◽  
Mesenchymal Transition ◽  
Human Liver Cancer

Abstract Background: The present study aimed to explore the role of ZIC4 in human liver cancer.Methods: Illumina450 genome-wide methylation data was downloaded from The Cancer Genome Atlas for 50 available liver tumor/surrounding pairs. Wound healing test, colony formation and flow cytometry assay were utilized to analyze cell migration, survival and apoptosis. The effects of EZH2 and ZIC4 on tumor growth were also investigated through in vivo xenograft and orthotopic implantation experiments. Results: ZIC4 was hypermethylated in liver cancer tissues and cell lines. EZH2 knockdown and DZNep mediated H3K27me3 contributes to ZIC4 expression. The antitumor effect of EZH2 knockdown on hepatocellular carcinoma growth, metastasis and epithelial-mesenchymal transition progression in vitro were rescued by sh-ZIC4. Downregulation of ZIC4 also rescued the antitumor effect of DZNep in vivo.Conclusions: Epigenetic silencing of ZIC4 by EZH2 mediated H3K27me3 is an important mechanism in human liver cancer and provide a new therapeutic target for the treatment of hepatocellular carcinoma disease.

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