scholarly journals Conditioned medium mimicking the tumor microenvironment augments chemotherapeutic resistance via ataxia‑telangiectasia mutated and nuclear factor‑κB pathways in gastric cancer cells

2018 ◽  
Author(s):  
Xinguo Zhuang ◽  
Xun Li ◽  
Jiaqin Zhang ◽  
Yi Hu ◽  
Bin Hu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Conditioned Medium ◽  
Ataxia Telangiectasia ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Ataxia Telangiectasia Mutated ◽  
Gastric Cancer Cells ◽  
Chemotherapeutic Resistance

scholarly journals Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells

Oncogene ◽  
2001 ◽  
Vol 20 (55) ◽  
pp. 8009-8018 ◽  
Author(s):  
Xiao-Hua Jiang ◽  
Benjamin Chun-Yu Wong ◽  
Marie Chia-Mi Lin ◽  
Geng-Hui Zhu ◽  
Hsiang-Fu Kung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Gastric Cancer Cells ◽  
Induced Apoptosis

BAY 11-7082, a nuclear factor-κB inhibitor, induces apoptosis and S phase arrest in gastric cancer cells

2013 ◽  
Vol 49 (5) ◽  
pp. 864-874 ◽  
Author(s):  
Ling Chen ◽  
Yuanyuan Ruan ◽  
Xuefei Wang ◽  
Lingqiang Min ◽  
Zhenbin Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
S Phase ◽  
Nuclear Factor ◽  
Gastric Cancer Cells ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Yes-Associated Protein Is Required for ZO-1-Mediated Tight-Junction Integrity and Cell Migration in E-Cadherin-Restored AGS Gastric Cancer Cells

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1264
Author(s):  
Seon-Young Kim ◽  
Song-Yi Park ◽  
Hwan-Seok Jang ◽  
Yong-Doo Park ◽  
Sun-Ho Kee
Keyword(s):  
Gastric Cancer ◽  
Cell Migration ◽  
Cancer Cells ◽  
Ectopic Expression ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Gastric Cancer Cells ◽  
Ags Cells ◽  
Migration Of Cells ◽  
E Cadherin

Yes-associated protein (YAP) regulates numerous cellular homeostasis processes and malignant transformation. We found that YAP influences ZO-1-mediated cell migration using E-cadherin-restored EC96 cells derived from gastric malignant AGS cells. Ectopic expression of E-cadherin enhanced straightforward migration of cells, in comparison to the meandering movement of parental AGS cells. In EC96 cells, YAP and ZO-1 expression increased but nuclear YAP levels and activity were reduced. Nuclear factor-κB (NF-κB) mediated the increase in ZO-1 expression, possibly stabilizing cytoplasmic YAP post-translationally. Downregulation of YAP expression using siYAP RNA or stable knock-down inhibited straightforward cell migration by fragmenting ZO-1 containing tight junctions (TJs) but not adherens junctions, implying involvement of YAP in ZO-1-mediated cell migration. The association of YAP with ZO-1 was mediated by angiomotin (AMOT) because downregulation of AMOT dissociated YAP from ZO-1 and reduced cell migration. E-cadherin restoration in malignant cancer cells induced NF-κB signaling to enhance ZO-1 expression and subsequently stabilize YAP. At high expression levels, YAP associates with ZO-1 via AMOT at TJs, influencing ZO-1-mediated cell migration and maintaining TJ integrity.

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