scholarly journals Prognostic impact of sarcopenia and its correlation with circulating miR-21 in colorectal cancer patients

Author(s):  
Yoshinaga Okugawa ◽  
Li Yao ◽  
Yuji Toiyama ◽  
Akira Yamamoto ◽  
Tsunehiko Shigemori ◽  
...  
2016 ◽  
Vol 31 (10) ◽  
pp. 1571 ◽  
Author(s):  
Eun Kyung Choe ◽  
Kyu Joo Park ◽  
Seung-Bum Ryoo ◽  
Sang Hui Moon ◽  
Heung-Kwon Oh ◽  
...  

2013 ◽  
Vol 24 ◽  
pp. iv101
Author(s):  
Noha Abbas ◽  
Omar Abdel-Rahman ◽  
Mohamed Ismail ◽  
Ahmed Rashad ◽  
Ehsan Algounemy

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e14515-e14515 ◽  
Author(s):  
Clarinda Wei Ling Chua ◽  
Dawn QQ Chong ◽  
Ravindran Kanesvaran ◽  
Wai Meng David Tai ◽  
Chee Kian Tham ◽  
...  

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15051-e15051
Author(s):  
Fangqi Liu ◽  
Jiang Zhao ◽  
Li Yang ◽  
Ji Zhu ◽  
Ye Xu

e15051 Background:The TNM classification system was widely used in managing many kinds of cancer including colorectal cancer. However, there is one undefined aspect that is the value of tumor deposits (TDs) in the condition of TDs and lymph nodes metastasis (LNM) coexisting. This research aims to clarify the prognostic impact of TDs in colorectal cancer especially for the condition of TDs combined with LNM. Methods: An analysis was performed to evaluate the prognostic significance of TDs in stage Ⅰ to Ⅳ colorectal cancer patients from 2010 to 2013 using Surveillance Epidemiology and End Results (SEER) database as a training cohort (N = 65, 537). An additional 3, 719 patients from Fudan University Shanghai Cancer Center were enrolled between 2006 and 2014 as a test cohort to validate the results. Results: TDs were observed in 6.32% of patients in training cohort and 14.7% in test cohort. A significantly reduced overall survival was observed for TDs positive in LNM positive and negative colorectal cancer patients (hazard ratio [HR], 1.65; 95% CI, 1.54 to 1.76). Further analysis combining TDs with LNM shows that there is no considerable difference in the impact on overall survival between N1 and N1c or between N1 with TDs (N1TD) and N2. The 3-year survival rate was 82.3%, 72.0%, 69.9%, 55.7%, 52.1%, 39.4% for N0, N1, N1c, N1TD, N2 and N2 with TDs (N2TD) respectively. Similar results were observed in the test cohort. Conclusions: These results support the 7th and 8th TNM system in which N1c was integrated into pathological N classification. However, LNM with positive TDs should be also considered into the TNM classification system because of the high prognostic impact of TDs, which was not mentioned in the current TNM system.


Author(s):  
Roberto Dinami ◽  
Manuela Porru ◽  
Carla Azzurra Amoreo ◽  
Isabella Sperduti ◽  
Marcella Mottolese ◽  
...  

2021 ◽  
Vol 18 (7) ◽  
pp. 1721-1729
Author(s):  
Xiaofei Wang ◽  
Yinghao Cao ◽  
Miaomiao Ding ◽  
Junqi Liu ◽  
Xiaoxiao Zuo ◽  
...  

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