scholarly journals miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma

2017 ◽  
Vol 38 (5) ◽  
pp. 2735-2740 ◽  
Author(s):  
Zhenwei Qiu ◽  
Hai Li ◽  
Jianwei Wang ◽  
Chongbing Sun
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Diagnosis And Prognosis

scholarly journals S100A1 is a Potential Biomarker for Papillary Thyroid Carcinoma Diagnosis and Prognosis

2021 ◽  
Vol 12 (19) ◽  
pp. 5760-5771
Author(s):  
Ge Wang ◽  
Han-ning Li ◽  
Xiao-qing Cui ◽  
Tao Xu ◽  
Meng-lu Dong ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Diagnosis And Prognosis ◽  
Potential Biomarker

BRAF Mutation Analysis of Fine-Needle Aspiration Biopsies of Papillary Thyroid Carcinoma: Impact on Diagnosis and Prognosis

2011 ◽  
Vol 55 (6) ◽  
pp. 563-569 ◽  
Author(s):  
Agnes Colanta ◽  
Oscar Lin ◽  
Laura Tafe ◽  
Ronald Ghossein ◽  
Khedoudja Nafa ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Mutation Analysis ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Fine Needle ◽  
Diagnosis And Prognosis

scholarly journals Estimation of Autophagy Activity By Evaluating Possible MicroRNA Biomarkers and FOXO1 mRNA Level in Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
Mojtaba Zehtabi ◽  
Amir Mahdi Khamnei ◽  
Siamak Salehi ◽  
Zahra Akbarpour ◽  
Yousef Roosta ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Mrna Level ◽  
Fold Increase ◽  
Papillary Thyroid ◽  
Tissue Samples ◽  
Diagnosis And Prognosis ◽  
Molecular Events ◽  
Autophagy Activity ◽  
Gene Expression Levels

Abstract Background: Papillary thyroid carcinoma (PTC) is the most prevalent endocrine malignancy. Despite nearly three-fold increase in incidence over three decades, the mortality rate remains unchanged. Biomarkers related to early diagnosis and prognosis of PTC are poorly investigated. Autophagy pathways and related miRNAs is considered to play an important role in PTC pathophysiology.Methods and Results: Tissue samples from patients with PTC undergoing thyroidectomy were collected. Total RNA content of tumor and margin samples were purified and converted to cDNA. Gene expression levels of mRNA (FOXO1) and miRNAs (miR-30d-5p, miR- 182-5p and miR-183-5p) were evaluated using qPCR method in PTC and adjacent normal tissue. A 6.51-fold decrease in miR-30d-5p level was detected in tumor samples compared to adjacent tissues. Moreover, miR-182-5p and miR-183-5p (FOXO1 as the main target) showed 1.73- and 4.31-fold increases in their levels, respectively. We also observed a 2.66-fold decrease in FOXO1 mRNA level in relation to these miRNA fold changes indicating a possible correlation between autophagy-linked molecular events and PTC.Conclusions: Significant increase in miR-183-5p and miR-182-5p expression, as well as a decrease in FOXO1 and miR-30d-5p expression, suggest that PTC has active autophagy machinery. This can possibly be used as a novel diagnostic or prognostic biomarker.

scholarly journals Predictive significance of serum MMP-9 in papillary thyroid carcinoma

2019 ◽  
Vol 14 (1) ◽  
pp. 275-287
Author(s):  
Dahai Xu ◽  
Chang Su ◽  
Liang Guo ◽  
He Yan ◽  
Shaokun Wang ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cox Regression ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Disease Free Survival ◽  
Papillary Thyroid ◽  
Diagnosis And Prognosis ◽  
Initial Surgery ◽  
Male Patients

AbstractObjectiveThe incidence of papillary thyroid carcinoma (PTC) is increasing, and there are no reliable serum biomarkers for the diagnosis and prognosis of PTC. This study aimed to assess whether serum matrix metalloproteinase-9 (MMP-9) could serve as an auxiliary diagnostic/prognostic marker for PTC after total and partial thyroidectomy.Material and MethodsPostoperative serum MMP-9 concentrations were measured in 182 male patients with PTC, 86 male patients with benign thyroid nodule (BTN), and 62 male healthy controls (HCs). Multivariate logistic regression and Cox regression were applied to evaluate the correlation between variables. The performance of serum MMP-9 in diagnosing PTC and predicting structural persistent/recurrent disease (SPRD) during 48 months of follow-up after initial surgery was evaluated by receiving operating characteristic curve analysis.ResultsThe median serum MMP-9 concentration in the PTC group (79.45 ng/ml) was significantly higher than those in the BTN group (47.35 ng/ml) and HC group (47.71 ng/ml). The area under the curve (AUC) for predicting PTC from BTN was 0.852 at a cut-off value of 60.59 ng/ml. Serum MMP-9 was negatively correlated with disease-free survival (OR 1.026, P=0.001). Serum MMP-9 exhibited good performance in predicting SPRD at a cutoff value of 99.25 ng/ml with an AUC of 0.818. Advanced TNM stage (OR 31.371, P=0.019) and serum MMP-9 ≥99.25 ng/ml (OR 4.103, P=0.022) were independent risk factors for SPRD.ConclusionsSerum MMP-9 potentially represents a good predictive biomarker for PTC diagnosis and prognosis after thyroidectomy in Chinese male patients for whom radio-imaging indicates suspected PTC.

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