scholarly journals Inhibition of the growth of hepatocellular carcinoma cells through fibroblast growth factor 18 suppressed by miR-139

2017 ◽  
Vol 38 (4) ◽  
pp. 2565-2571 ◽  
Author(s):  
Li Yang ◽  
Dian Yin ◽  
Yilang Wang ◽  
Lili Cao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Carcinoma Cells ◽  
Fibroblast Growth ◽  
Hepatocellular Carcinoma Cells

scholarly journals Fibroblast growth factor-2 enhances NK sensitivity of hepatocellular carcinoma cells

2011 ◽  
Vol 130 (2) ◽  
pp. 356-364 ◽  
Author(s):  
Hinako Tsunematsu ◽  
Tomohide Tatsumi ◽  
Keisuke Kohga ◽  
Masashi Yamamoto ◽  
Hiroshi Aketa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Carcinoma Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Hepatocellular Carcinoma Cells

Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer

1994 ◽  
Vol 14 (12) ◽  
pp. 7758-7769
Author(s):  
L Dailey ◽  
H Yuan ◽  
C Basilico
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Binding Proteins ◽  
Embryonal Carcinoma ◽  
Carcinoma Cells ◽  
Specific Factor ◽  
Fibroblast Growth ◽  
Embryonal Carcinoma Cells ◽  
Enhancer Function ◽  
Restricted Activity

Understanding how diverse transcription patterns are achieved through common factor binding elements is a fundamental question that underlies much of developmental and cellular biology. One example is provided by the fibroblast growth factor 4 (FGF-4) gene, whose expression is restricted to specific embryonic tissues during development and to undifferentiated embryonal carcinoma cells in tissue culture. Analysis of the cis- and trans-acting elements required for the activity of the previously identified FGF-4 enhancer in F9 embryonal carcinoma cells showed that enhancer function depends on sequences that bind Sp1 and ubiquitous as well as F9-specific octamer-binding proteins. However, sequences immediately upstream of the octamer motif, which conform to a binding site for the high-mobility group (HMG) domain factor family, were also critical to enhancer function. We have identified a novel F9-specific factor, Fx, which specifically recognizes this motif. Fx formed complexes with either Oct-1 or Oct-3 in a template-dependent manner. The ability of different enhancer variants to form the Oct-Fx complexes correlated with enhancer activity, indicating that these complexes play an essential role in transcriptional activation of the FGF-4 gene. Thus, while FGF-4 enhancer function is octamer site dependent, its developmentally restricted activity is determined by the interaction of octamer-binding proteins with the tissue-specific factor Fx.

scholarly journals Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

Hepatology ◽  
2008 ◽  
Vol 47 (4) ◽  
pp. 1211-1222 ◽  
Author(s):  
Jin-Ping Lai ◽  
Dalbir S. Sandhu ◽  
Chunrong Yu ◽  
Tao Han ◽  
Catherine D. Moser ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Signaling
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