scholarly journals KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells

2017 ◽  
Vol 38 (1) ◽  
pp. 481-487 ◽  
Author(s):  
Yang Liu ◽  
Dong-Yeop Shin ◽  
Somi Oh ◽  
Sujong Kim ◽  
Youngil Koh ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Lymphoid Leukemia ◽  
Acute Lymphoid Leukemia ◽  
Antileukemic Effect

Abstract 5378: SB225002 induces apoptosis in acute lymphoid leukemia cells

2011 ◽  
Author(s):  
Jaira F. Vasconcellos ◽  
Angelo B. A. Laranjeira ◽  
Paulo C. Leal ◽  
Ricardo J. Nunes ◽  
Rosendo A. Yunes ◽  
...  
Keyword(s):  
Leukemia Cells ◽  
Lymphoid Leukemia ◽  
Acute Lymphoid Leukemia

Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A

2015 ◽  
Vol 53 (9-10) ◽  
pp. 268-279 ◽  
Author(s):  
Jianzhen Shen ◽  
Junnan Su ◽  
Dansen Wu ◽  
Feng Zhang ◽  
Haiying Fu ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Leukemia Cells ◽  
Lymphoid Leukemia ◽  
Acute Lymphoid Leukemia

scholarly journals Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways

2021 ◽  
Vol 22 (8) ◽  
pp. 4265
Author(s):  
Jang Mi Han ◽  
Hong Lae Kim ◽  
Hye Jin Jung
Keyword(s):  
Signaling Pathways ◽  
Cell Lines ◽  
White Blood Cells ◽  
Leukemia Cell ◽  
Leukemia Cells ◽  
Ros Generation ◽  
Anticancer Activities ◽  
Nuclear Condensation ◽  
Leukemia Cell Lines ◽  
Antileukemic Effect

Leukemia is a type of blood cancer caused by the rapid proliferation of abnormal white blood cells. Currently, several treatment options, including chemotherapy, radiation therapy, and bone marrow transplantation, are used to treat leukemia, but the morbidity and mortality rates of patients with leukemia are still high. Therefore, there is still a need to develop more selective and less toxic drugs for the effective treatment of leukemia. Ampelopsin, also known as dihydromyricetin, is a plant-derived flavonoid that possesses multiple pharmacological functions, including antibacterial, anti-inflammatory, antioxidative, antiangiogenic, and anticancer activities. However, the anticancer effect and mechanism of action of ampelopsin in leukemia remain unclear. In this study, we evaluated the antileukemic effect of ampelopsin against acute promyelocytic HL60 and chronic myelogenous K562 leukemia cells. Ampelopsin significantly inhibited the proliferation of both leukemia cell lines at concentrations that did not affect normal cell viability. Ampelopsin induced cell cycle arrest at the sub-G1 phase in HL60 cells but the S phase in K562 cells. In addition, ampelopsin regulated the expression of cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors differently in each leukemia cell. Ampelopsin also induced apoptosis in both leukemia cell lines through nuclear condensation, loss of mitochondrial membrane potential, increase in reactive oxygen species (ROS) generation, activation of caspase-9, caspase-3, and poly ADP-ribose polymerase (PARP), and regulation of Bcl-2 family members. Furthermore, the antileukemic effect of ampelopsin was associated with the downregulation of AKT and NF-κB signaling pathways. Moreover, ampelopsin suppressed the expression levels of leukemia stemness markers, such as Oct4, Sox2, CD44, and CD133. Taken together, our findings suggest that ampelopsin may be an attractive chemotherapeutic agent against leukemia.

WBC-reduced blood transfusions and clinical outcome in children with acute lymphoid leukemia

Transfusion ◽  
2001 ◽  
Vol 41 (7) ◽  
pp. 873-877 ◽  
Author(s):  
Jorge A. Rios ◽  
David N. Korones ◽  
Joanna M. Heal ◽  
Neil Blumberg
Keyword(s):  
Clinical Outcome ◽  
Blood Transfusions ◽  
Lymphoid Leukemia ◽  
Acute Lymphoid Leukemia

Retrospective Study of Adults With Acute Lymphoid Leukemia in Mexico City: First Report of the Working Group for Acute Leukemia (GTLA)

2017 ◽  
Vol 17 ◽  
pp. S252
Author(s):  
Erick Crespo-Solis ◽  
Karla Espinosa-Bautista ◽  
Martha Alvarado-Ibarra ◽  
Etta Rozen-Fuller ◽  
Fernando Perez-Rocha ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Acute Leukemia ◽  
Mexico City ◽  
Working Group ◽  
Lymphoid Leukemia ◽  
First Report ◽  
Acute Lymphoid Leukemia

scholarly journals Macroglobulinemia in a Child With Acute Leukemia

Blood ◽  
1974 ◽  
Vol 43 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Jan Čejka ◽  
Robert O. Bollinger ◽  
Henrica R.E. Schuit ◽  
Jeanne M. Lusher ◽  
Chung-Ho Chang ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Immunoglobulin M ◽  
Leukemia Cells ◽  
Bence Jones Protein ◽  
Electron Microscopic ◽  
Lymphoid Leukemia ◽  
Β2 Microglobulin ◽  
Immunofluorescence Studies ◽  
Bence Jones Proteinuria ◽  
Serum And Urine

Abstract A 12-yr-old boy with acute leukemia was found to have paraproteinemia and Bence-Jones proteinuria. The paraprotein was characterized as immunoglobulin M, type κ and the Bence Jones protein as free κ-chains. Increased amounts of β2-microglobulin were found in the patient’s serum and urine. Electron microscopic and immunofluorescence studies provided evidence of the presence of lymphoid leukemia cells apparently responsible for the production of the paraprotein.

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