scholarly journals Fisetin inhibits liver cancer growth in a mouse model: Relation to dopamine receptor

2017 ◽  
Vol 38 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Xiang-Feng Liu ◽  
Hai-Jiao Long ◽  
Xiong-Ying Miao ◽  
Guo-Li Liu ◽  
Hong-Liang Yao
Keyword(s):  
Liver Cancer ◽  
Mouse Model ◽  
Dopamine Receptor ◽  
Cancer Growth ◽  
Model Relation

scholarly journals Angelicin inhibits liver cancer growth in vitro and in vivo

2017 ◽  
Vol 16 (4) ◽  
pp. 5441-5449 ◽  
Author(s):  
Fengliang Wang ◽  
Jun Li ◽  
Rong Li ◽  
Guohua Pan ◽  
Mingxia Bai ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Growth

scholarly journals IGF2BP2 Promotes Liver Cancer Growth Through an m6A-FEN1-Dependent Mechanism

2020 ◽  
Vol 10 ◽  
Author(s):  
Jian Pu ◽  
Jianchu Wang ◽  
Zebang Qin ◽  
Anmin Wang ◽  
Ya Zhang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Growth ◽  
Dependent Mechanism

Abstract 5239: Preventive effects of pentoxifylline on hepatic tumorigenesis in a novel mouse model of NASH-related liver cancer

2016 ◽  
Author(s):  
Yohei Shirakami ◽  
Akinori Maruta ◽  
Koki Obara ◽  
Takayasu Ideta ◽  
Tsuneyuki Miyazaki ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Mouse Model ◽  
Preventive Effects ◽  
Hepatic Tumorigenesis

scholarly journals Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 393 ◽  
Author(s):  
Lulu Xie ◽  
Minjing Li ◽  
Desheng Liu ◽  
Xia Wang ◽  
Peiyuan Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Mouse Model ◽  
Colony Formation ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Small Interfering Rnas ◽  
Nude Mouse Model ◽  
Hep3b Cells

Liver cancer is a very common and significant health problem. Therefore, powerful molecular targeting agents are urgently needed. Previously, we demonstrated that secalonic acid-F (SAF) suppresses the growth of hepatocellular carcinoma (HCC) cells (HepG2), but the other anticancer biological functions and the underlying mechanism of SAF on HCC are unknown. In this study, we found that SAF, which was isolated from a fungal strain in our lab identified as Aspergillus aculeatus, could inhibit the progression of hepatocellular carcinoma by targeting MARCH1, which regulates the PI3K/AKT/β-catenin and antiapoptotic Mcl-1/Bcl-2 signaling cascades. First, we confirmed that SAF reduced the proliferation and colony formation of HCC cell lines (HepG2 and Hep3B), promoted cell apoptosis, and inhibited the cell cycle in HepG2 and Hep3B cells in a dose-dependent manner. In addition, the migration and invasion of HepG2 and Hep3B cells treated with SAF were significantly suppressed. Western blot analysis showed that the level of MARCH1 was downregulated by pretreatment with SAF through the regulation of the PI3K/AKT/β-catenin signaling pathways. Moreover, knockdown of MARCH1 by small interfering RNAs (siRNAs) targeting MARCH1 also suppressed the proliferation, colony formation, migration, and invasion as well as increased the apoptotic rate of HepG2 and Hep3B cells. These data confirmed that the downregulation of MARCH1 could inhibit the progression of hepatocellular carcinoma and that the mechanism may be via PI3K/AKT/β-catenin inactivation as well as the downregulation of the antiapoptotic Mcl-1/Bcl-2. In vivo, the downregulation of MARCH1 by treatment with SAF markedly inhibited tumor growth, suggesting that SAF partly blocks MARCH1 and further regulates the PI3K/AKT/β-catenin and antiapoptosis Mcl-1/Bcl-2 signaling cascade in the HCC nude mouse model. Additionally, the apparent diffusion coefficient (ADC) values, derived from magnetic resonance imaging (MRI), were increased in tumors after SAF treatment in a mouse model. Taken together, our findings suggest that MARCH1 is a potential molecular target for HCC treatment and that SAF is a promising agent targeting MARCH1 to treat liver cancer patients.

scholarly journals Gene Signatures Derived from a c-MET-Driven Liver Cancer Mouse Model Predict Survival of Patients with Hepatocellular Carcinoma

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24582 ◽  
Author(s):  
Irena Ivanovska ◽  
Chunsheng Zhang ◽  
Angela M. Liu ◽  
Kwong F. Wong ◽  
Nikki P. Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Mouse Model ◽  
Gene Signatures

scholarly journals Inhibition of squamous cancer growth in a mouse model by Staphylococcal enterotoxin B-triggered Th9 cell expansion

2015 ◽  
Vol 14 (4) ◽  
pp. 371-379 ◽  
Author(s):  
Bei-Ping Miao ◽  
Rui-Shi Zhang ◽  
Huan-Ji Sun ◽  
Yan-Ping Yu ◽  
Tao Chen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cell Expansion ◽  
Staphylococcal Enterotoxin ◽  
Cancer Growth ◽  
Staphylococcal Enterotoxin B ◽  
Squamous Cancer ◽  
Enterotoxin B ◽  
Th9 Cell
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