scholarly journals p21-activated protein kinase 1 induces the invasion of gastric cancer cells through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase-2

2017 ◽  
Vol 38 (1) ◽  
pp. 193-200 ◽  
Author(s):  
Liang-Hui Li ◽  
Guo-Yang Wu ◽  
Yi-Zhuo Lu ◽  
Xue-Hua Chen ◽  
Bing-Ya Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Matrix Metalloproteinase 2 ◽  
Gastric Cancer Cells

Accurate detection of matrix metalloproteinase-2 activity in clinical gastric cancer tissues using a fluorescent probe

2019 ◽  
Vol 11 (11) ◽  
pp. 1516-1521 ◽  
Author(s):  
Fujuan Luan ◽  
Zuhong Yu ◽  
Ling Yin ◽  
Xia Leng ◽  
Yuxue Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Matrix Metalloproteinase 2 ◽  
Gastric Cancer Cells ◽  
New Approach ◽  
Accurate Detection ◽  
Cancer Tissues

A new approach for specific and accurate detection of the activated MMP-2 both in gastric cancer cells and clinical tissues using a fluorescent probe is described here.

scholarly journals PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways

2020 ◽  
Vol 28 (3) ◽  
pp. 213-223 ◽  
Author(s):  
Yangmei Zhang ◽  
Xichang Zhou ◽  
Long Cheng ◽  
Xiang Wang ◽  
Qinglin Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Akt Signaling ◽  
Catalytic Subunit ◽  
Gastric Cancer Cells ◽  
In Vivo Experiments ◽  
Compound C ◽  
Amp Activated Protein Kinase

PRKAA1 (protein kinase AMP-activated catalytic subunit α 1) is a catalytic subunit of AMP-activated protein kinase (AMPK), which plays a key role in regulating cellular energy metabolism through phosphorylation, and genetic variations in the PRKAA1 have been found to be associated with gastric cancer risk. However, the effect and underlying molecular mechanism of PRKAA1 on gastric cancer tumorigenesis, especially the proliferation and apoptosis, are not fully understood. Our data showed that PRKAA1 is highly expressed in BGC-823 and MKN45 cells and is expressed low in SGC-7901 and MGC-803 cells in comparison with the other gastric cancer cells. PRKAA1 downregulation by shRNA or treatment of AMPK inhibitor compound C significantly inhibited proliferation as well as promoted cell cycle arrest and apoptosis of BGC-823 and MKN45 cells. Moreover, the expression of PCNA and Bcl-2 and the activity of JNK1 and Akt signaling were also reduced in BGC-823 and MKN45 cells after PRKAA1 downregulation. In vivo experiments demonstrated that tumor growth in nude mice was significantly inhibited after PRKAA1 silencing. Importantly, inactivation of JNK1 or Akt signaling pathway significantly inhibited PRKAA1 overexpression-induced increased cell proliferation and decreased cell apoptosis in MGC-803 cells. In conclusion, our findings suggest that PRKAA1 increases proliferation and restrains apoptosis of gastric cancer cells through activating JNK1 and Akt pathways.

scholarly journals Type II cGMP-dependent protein kinase inhibits ligand-induced activation of EGFR in gastric cancer cells

2014 ◽  
Vol 9 (4) ◽  
pp. 1405-1409 ◽  
Author(s):  
LU JIANG ◽  
YONGCHANG CHEN ◽  
YUEYING LI ◽  
TING LAN ◽  
MIN WU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Type Ii ◽  
Gastric Cancer Cells ◽  
Dependent Protein Kinase ◽  
Cgmp Dependent Protein Kinase ◽  
Dependent Protein

Potentiation of Apoptosis by Treatment With the Protein Kinase C-Specific Inhibitor Safingol in Mitomycin C-Treated Gastric Cancer Cells

1995 ◽  
Vol 87 (18) ◽  
pp. 1394-1399 ◽  
Author(s):  
G. K. Schwartz ◽  
A. Haimovitz-Friedman ◽  
S. K. Dhupar ◽  
D. Ehleiter ◽  
P. Maslak ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Mitomycin C ◽  
Specific Inhibitor ◽  
Gastric Cancer Cells ◽  
Kinase C

scholarly journals Protein kinase Cα promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage

Oncogene ◽  
1999 ◽  
Vol 18 (40) ◽  
pp. 5604-5609 ◽  
Author(s):  
Hiroyuki Okuda ◽  
Masaaki Adachi ◽  
Masaaki Miyazawa ◽  
Yuji Hinoda ◽  
Kohzoh Imai
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Gastric Cancer Cells ◽  
Protein Kinase Cα
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