scholarly journals SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K/Akt signaling pathway

2017 ◽  
Vol 37 (5) ◽  
pp. 2575-2582 ◽  
Author(s):  
Bin Zhu ◽  
Dongdong Cheng ◽  
Lei Hou ◽  
Shumin Zhou ◽  
Tao Ying ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Human Osteosarcoma

scholarly journals miR-92a promotes tumor growth of osteosarcoma by targeting PTEN/AKT signaling pathway

2017 ◽  
Vol 37 (4) ◽  
pp. 2513-2521 ◽  
Author(s):  
Jie Xiao ◽  
Weifeng Yu ◽  
Kongzu Hu ◽  
Maoqiang Li ◽  
Jianwei Chen ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway

Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model

2018 ◽  
Vol 9 (11) ◽  
pp. 5513-5527 ◽  
Author(s):  
Yannan Liu ◽  
Daidi Fan
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Tumor Growth ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Pathway ◽  
Akt Signaling Pathway ◽  
Ginsenoside Rg5 ◽  
Induced Apoptosis

Ginsenoside Rg5 significantly suppressed tumor growth and induced apoptosis and autophagy through the inhibition of the PI3K/Akt signaling pathway.

scholarly journals LncRNA MALAT1 Promotes Cancer Metastasis in Osteosarcoma via Activation of the PI3K-Akt Signaling Pathway

2018 ◽  
Vol 51 (3) ◽  
pp. 1313-1326 ◽  
Author(s):  
Yong  Chen ◽  
Wending Huang ◽  
Wei Sun ◽  
Biqiang Zheng ◽  
Chunmeng Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tumor Growth ◽  
Signaling Pathway ◽  
Cancer Metastasis ◽  
Soft Tissues ◽  
Akt Signaling ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Osteosarcoma Cell ◽  
Akt Signaling Pathway

Background/Aims: LncRNAs have been reported to be vital regulators of the progression of osteosarcoma, although the underlying mechanisms are not completely understood. Methods: The levels of MALAT1 and miR-129-5p expression were measured using qRT-PCR. Cell growth was determined using the CCK-8 and colony formation assays. Cell migration and invasion were detected using the wound healing and Transwell invasion assays, respectively. Tumor growth was determined with a xenograft model. Results: MALAT1 was significantly up-regulated in osteosarcoma tissues compared with adjacent non-tumor soft tissues. Overexpression of MALAT1 promoted osteosarcoma cell proliferation, migration, and invasion in vitro and enhanced tumor growth in a tumor xenograft mouse model. MALAT1 promoted osteosarcoma progression by modulating stem cell-like properties. Moreover, rescue experiment and luciferase reporter assay results indicated that MALAT1 modulates RET expression by sponging miR-129-5p in osteosarcomas. Furthermore, MALAT1 augmented the expression of downstream proteins of the RET-Akt pathway. MALAT1 was consistently significantly increased in osteosarcoma tissues and MALAT1 expression was positively correlated with tumor size and metastasis. High expression of MALAT1 was significantly associated with poor outcomes in patients with osteosarcomas. MALAT1 expression was positively related to RET and negatively related to miR-129-5p in osteosarcoma samples and xenograft tumors. MALAT1 functioned as an oncogenic lncRNA in osteosarcomas and was as an independent prognostic indicator. Conclusion: Our data revealed for the first time that MALAT1 increases stem cell-like properties by up-regulating RET via sponging miR-129-5p, and thus activates the PI3K-Akt signaling pathway and provides potential therapeutic targets for osteosarcoma treatment.

SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer

2017 ◽  
Vol 482 (4) ◽  
pp. 870-876 ◽  
Author(s):  
Jiaxuan Zhang ◽  
Xiaofei Zhi ◽  
Shiyu Shi ◽  
Ran Tao ◽  
Peisheng Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway

CXCL8 promotes the invasion of human osteosarcoma cells by regulation of PI3K/Akt signaling pathway

Apmis ◽  
2017 ◽  
Vol 125 (9) ◽  
pp. 773-780 ◽  
Author(s):  
Hai Jiang ◽  
Xiaowei Wang ◽  
Wusheng Miao ◽  
Bing Wang ◽  
Yusheng Qiu
Keyword(s):  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells
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