scholarly journals TP53 and RET may serve as biomarkers of prognostic evaluation and targeted therapy in hepatocellular carcinoma

2017 ◽  
Vol 37 (4) ◽  
pp. 2215-2226 ◽  
Author(s):  
Song Ye ◽  
Xin-Yi Zhao ◽  
Xiao-Ge Hu ◽  
Tang Li ◽  
Qiu-Ran Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy ◽  
Prognostic Evaluation

scholarly journals Eastern asian expert panel opinion: designing clinical trials of molecular targeted therapy for hepatocellular carcinoma

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Winnie Yeo ◽  
Pei-Jer Chen ◽  
Junji Furuse ◽  
Kwang-Hyub Han ◽  
Chiun Hsu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Trials ◽  
Targeted Therapy ◽  
Molecular Targeted Therapy ◽  
Expert Panel

scholarly journals How to assess the efficacy or failure of targeted therapy: Deciding when to stop sorafenib in hepatocellular carcinoma

2016 ◽  
Vol 8 (35) ◽  
pp. 1541 ◽  
Author(s):  
Jean-Luc Raoul ◽  
Xavier Adhoute ◽  
Marine Gilabert ◽  
Julien Edeline
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy

scholarly journals Therapeutic response monitoring after targeted therapy in an orthotopic rat model of hepatocellular carcinoma using contrast-enhanced ultrasound: Focusing on inter-scanner, and inter-operator reproducibility

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244304
Author(s):  
Hwaseong Ryu ◽  
Jung Hoon Kim ◽  
Seunghyun Lee ◽  
Joon Koo Han
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy ◽  
Treatment Group ◽  
Rat Model ◽  
Therapeutic Response ◽  
Response Monitoring ◽  
Control Group ◽  
Rat Models ◽  
Significant Change ◽  
Operator Reproducibility

Purpose To assess therapeutic response monitoring after targeted therapy in an orthotopic rat model of hepatocellular carcinoma (HCC) using CEUS with focusing on inter-scanner and inter-operator reproducibility. Materials and methods For reproducibility, CEUS was performed using two different US scanners by two operators in sixteen rat models of HCC. Using perfusion analysis software (VueBox ®), eleven parameters were collected, and intra-class correlation coefficient (ICC) was used to analyze reproducibility. Then seventeen rat models of HCC were divided into treatment group (n = 8, 30 mg/kg/day sorafenib for five days) and control group (n = 9). CEUS was performed at baseline and 14 days after first treatment, and changes of perfusion parameters were analyzed. Results In treatment group, CEUS perfusion parameters showed a significant change. The peak enhancement (PE, 2.50 x103±1.68 x103 vs 5.55x102±4.65x102, p = 0.010) and wash-in and wash out AUC (WiWoAUC, 1.07x105±6.48 x104 vs 2.65x104±2.25x104, p = 0.009) had significantly decreased two weeks after treatment. On the contrary, control group did not show a significant change, including PE (1.15 x103±7.53x102 vs 9.43x102± 7.81 x102, p = 0.632) and WiWoAUC (5.09 x104±3.25x104 vs 5.92 x104±3.20x104, p = 0.646). For reproducibility, the various degrees of inter-scanner reproducibility were from poor to good (ICC: <0.01–0.63). However, inter-operator reproducibility of important perfusion parameters, including WiAUC, WoAUC, and WiWoAUC, ranged from fair to excellent (ICC: 0.59–0.93) in a different scanner. Conclusion Our results suggest that CEUS is useful for assessment of the treatment response after targeted therapy and with fair to excellent inter-operator reproducibility.

Glycosylated 4‐methylumbelliferone as a targeted therapy for hepatocellular carcinoma

2021 ◽  
Author(s):  
Gisela Weiz ◽  
Maria I. Molejon ◽  
Mariana Malvicini ◽  
Caecilia H. C. Sukowati ◽  
Claudio Tiribelli ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy

scholarly journals Angiogenesis in Hepatocellular Carcinoma; Pathophysiology, Targeted Therapy, and Role of Imaging

2020 ◽  
Vol Volume 7 ◽  
pp. 77-89 ◽  
Author(s):  
Ahmed W Moawad ◽  
Janio Szklaruk ◽  
Chandana Lall ◽  
Katherine J Blair ◽  
Ahmed O Kaseb ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy

scholarly journals Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma

2016 ◽  
Vol Volume 11 ◽  
pp. 5645-5669 ◽  
Author(s):  
Min Li ◽  
Weiyue Zhang ◽  
Birong Wang ◽  
Yang Gao ◽  
Zifang Song ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy ◽  
Novel Strategy
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