scholarly journals Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway

2016 ◽  
Vol 37 (2) ◽  
pp. 865-870 ◽  
Author(s):  
Huanhuan Chen ◽  
Yuechun Huang ◽  
Junbin Huang ◽  
Lizhen Lin ◽  
Gang Wei
Keyword(s):  
Liver Cancer ◽  
Signaling Pathway ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Human Liver Cancer

scholarly journals Assessment of Chemopreventive Potential of the Plant Extracts against Liver Cancer Using Hepg2 Cell Line

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4593
Author(s):  
Deepthi Venkatachalapathy ◽  
Chandan Shivamallu ◽  
Shashanka Prasad ◽  
Gopenath Thangaraj Saradha ◽  
Parthiban Rudrapathy ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Vitis Vinifera ◽  
Bioactive Compounds ◽  
Camellia Sinensis ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Withania Somnifera ◽  
Antioxidant Properties ◽  
Annexin V ◽  
Human Liver Cancer

The edible parts of the plants Camellia sinensis, Vitis vinifera and Withania somnifera were extensively used in ancient practices such as Ayurveda, owing to their potent biomedical significance. They are very rich in secondary metabolites such as polyphenols, which are very good antioxidants and exhibit anti-carcinogenic properties. This study aims to evaluate the anti-cancerous properties of these plant crude extracts on human liver cancer HepG2 cells. The leaves of Camellia sinensis, Withania somnifera and the seeds of Vitis vinifera were collected and methanolic extracts were prepared. Then, these extracts were subjected to DPPH, α- amylase assays to determine the antioxidant properties. A MTT assay was performed to investigate the viability of the extracts of HepG2 cells, and the mode of cell death was detected by Ao/EtBr staining and flow cytometry with PI Annexin- V FITC dual staining. Then, the protein expression of BAX and BCl2 was studied using fluorescent dye to determine the regulation of the BAX and BCl2 genes. We observed that all the three extracts showed the presence of bioactive compounds such as polyphenols or phytochemicals. The W. somnifera bioactive compounds were found to have the highest anti-proliferative activity on human liver cancer cells.

scholarly journals Cordycepin induces apoptosis in human liver cancer HepG2 cells through extrinsic and intrinsic signaling pathways

2016 ◽  
Vol 12 (2) ◽  
pp. 995-1000 ◽  
Author(s):  
Le-Wen Shao ◽  
Li-Hua Huang ◽  
Sheng Yan ◽  
Jian-Di Jin ◽  
Shao-Yan Ren
Keyword(s):  
Liver Cancer ◽  
Signaling Pathways ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Human Liver Cancer

scholarly journals Effects of artemisinin on proliferation and apoptosis of human liver cancer HepG2 cells

Medicine ◽  
2020 ◽  
Vol 99 (20) ◽  
pp. e20290
Author(s):  
Jing Li ◽  
Zhi-ye Liu ◽  
Hai-bo Yu ◽  
Qing Xue ◽  
Xiu-sheng Qu
Keyword(s):  
Liver Cancer ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Proliferation And Apoptosis ◽  
Human Liver Cancer

Effect of Bmi-1-mediated NF-κB signaling pathway on the stem-like properties of CD133+ human liver cancer cells

2018 ◽  
Vol 22 (3) ◽  
pp. 575-585 ◽  
Author(s):  
De-Qiang Ma ◽  
Yin-Hua Zhang ◽  
De-Ping Ding ◽  
Juan Li ◽  
Lin-Li Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals RTCA Monitors the Inhibitory Effect of SWCNTs on the Proliferation of human liver cancer HepG2 cells

2019 ◽  
Vol 563 ◽  
pp. 052070
Author(s):  
Boya Zhang ◽  
Lei Yang ◽  
Hua Wang ◽  
Ming Liu ◽  
Xiuxia Zhang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Inhibitory Effect ◽  
Human Liver Cancer
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