scholarly journals Nitidine chloride inhibits the malignant behavior of human glioblastoma cells by targeting the PI3K/AKT/mTOR signaling pathway

2016 ◽  
Vol 36 (4) ◽  
pp. 2160-2168 ◽  
Author(s):  
Ming Liu ◽  
Jiwei Wang ◽  
Qichao Qi ◽  
Bin Huang ◽  
Anjing Chen ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells ◽  
Malignant Behavior

scholarly journals Amlexanox Enhances Temozolomide-Induced Antitumor Effects in Human Glioblastoma Cells by Inhibiting IKBKE and the Akt-mTOR Signaling Pathway

ACS Omega ◽  
2021 ◽  
Vol 6 (6) ◽  
pp. 4289-4299
Author(s):  
Jinbiao Xiong ◽  
Gaochao Guo ◽  
Lianmei Guo ◽  
Zengguang Wang ◽  
Zhijuan Chen ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Glioblastoma Cells ◽  
Antitumor Effects ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

scholarly journals Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway

2019 ◽  
Vol Volume 13 ◽  
pp. 1023-1032 ◽  
Author(s):  
Jingren Shi ◽  
Wenli Zhang ◽  
Lu He ◽  
Fanhong Kong ◽  
Meichen Pan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Migration And Invasion ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway

2019 ◽  
Vol 1717 ◽  
pp. 117-126 ◽  
Author(s):  
Xiang Ding ◽  
Gang Deng ◽  
Junhui Liu ◽  
Baohui Liu ◽  
Fan'en Yuan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Human Glioblastoma Cells

scholarly journals Rutaecarpine Inhibits U87 Glioblastoma Cell Migration by Activating the Aryl Hydrocarbon Receptor Signaling Pathway

2021 ◽  
Vol 14 ◽  
Author(s):  
Yiyun Liu ◽  
Yangsheng Chen ◽  
Ruihong Zhu ◽  
Li Xu ◽  
Heidi Qunhui Xie ◽  
...  
Keyword(s):  
Cell Migration ◽  
Aryl Hydrocarbon Receptor ◽  
Signaling Pathway ◽  
Dependent Manner ◽  
Glioblastoma Cell ◽  
Glioblastoma Cells ◽  
Migration Ability ◽  
Human Glioblastoma ◽  
Aryl Hydrocarbon ◽  
Human Glioblastoma Cells

Glioblastoma is the most frequent and aggressive primary astrocytoma in adults. The high migration ability of the tumor cells is an important reason for the high recurrence rate and poor prognosis of glioblastoma. Recently, emerging evidence has shown that the migration ability of glioblastoma cells was inhibited upon the activation of aryl hydrocarbon receptor (AhR), suggesting potential anti-tumor effects of AhR agonists. Rutaecarpine is a natural compound with potential tumor therapeutic effects which can possibly bind to AhR. However, its effect on the migration of glioblastoma is unclear. Therefore, we aim to explore the effects of rutaecarpine on the migration of human glioblastoma cells U87 and the involvement of the AhR signaling pathway. The results showed that: (i) compared with other structural related alkaloids, like evodiamine and dehydroevodiamine, rutaecarpine was a more potent AhR activator, and has a stronger inhibitory effect on the glioblastoma cell migration; (ii) rutaecarpine decreased the migration ability of U87 cells in an AhR-dependent manner; (iii) AhR mediated the expression of a tumor suppressor interleukin 24 (IL24) induced by rutaecarpine, and AhR-IL24 axis was involved in the anti-migratory effects of rutaecarpine on the glioblastoma. Besides IL24, other candidates AhR downstream genes both associated with cancer and migration were proposed to participate in the migration regulation of rutaecarpine by RNA-Seq and bioinformatic analysis. These data indicate that rutaecarpine is a naturally-derived AhR agonist that could inhibit the migration of U87 human glioblastoma cells mostly via the AhR-IL24 axis.

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