scholarly journals Genome-wide analysis of the effect of esophageal squamous cell carcinoma on human umbilical vein endothelial cells

2016 ◽  
Vol 36 (1) ◽  
pp. 155-164 ◽  
Author(s):  
GUOGUO JIN ◽  
YI YANG ◽  
HANGFAN LIU ◽  
KANGDONG LIU ◽  
JIMIN ZHAO ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Endothelial Cells ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Umbilical Vein Endothelial Cells

Genome-wide analysis of gene expression by crotonaldehyde in human umbilical vein endothelial cells

2011 ◽  
Vol 7 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Seong Il Jeong ◽  
Seung Eun Lee ◽  
Hana Yang ◽  
Cheung-Seog Park ◽  
Jeong-Je Cho ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Umbilical Vein ◽  
Human Umbilical Vein ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Umbilical Vein Endothelial Cells

scholarly journals Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Shirui Chen ◽  
Kai Zhou ◽  
Liguang Yang ◽  
Guohui Ding ◽  
Hong Li
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Racial Differences ◽  
Squamous Cell ◽  
Geographic Location ◽  
Molecular Features ◽  
Genome Wide ◽  
White Patients

The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer.

Abstract 31: Genome-wide association study of African esophageal squamous cell carcinoma

2021 ◽  
Author(s):  
Wenlong C. Chen ◽  
Jean-Tristan Brandenburg ◽  
Ananyo Choudhury ◽  
Mahtaab Hayat ◽  
Dhriti Sengupta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Association Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide
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