scholarly journals Targeting cryptic epitope with modified antigen coupled to the surface of liposomes induces strong antitumor CD8 T-cell immune responses in vivo

2015 ◽  
Vol 34 (6) ◽  
pp. 2827-2836 ◽  
Author(s):  
YUTAKA HORIUCHI ◽  
AKIRA TAKAGI ◽  
TETSUYA UCHIDA ◽  
TOSHITAKA AKATSUKA
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Cd8 T Cell ◽  
Cryptic Epitope ◽  
T Cell Immune Responses

scholarly journals Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Mauro Di Pilato ◽  
Miguel Palomino-Segura ◽  
Ernesto Mejías-Pérez ◽  
Carmen E. Gómez ◽  
Andrea Rubio-Ponce ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Vaccinia Virus ◽  
Adaptive Immune System ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Adaptive Immune

AbstractNeutrophils are innate immune cells involved in the elimination of pathogens and can also induce adaptive immune responses. Nα and Nβ neutrophils have been described with distinct in vitro capacity to generate antigen-specific CD8 T-cell responses. However, how these cell types exert their role in vivo and how manipulation of Nβ/Nα ratio influences vaccine-mediated immune responses are not known. In this study, we find that these neutrophil subtypes show distinct migratory and motility patterns and different ability to interact with CD8 T cells in the spleen following vaccinia virus (VACV) infection. Moreover, after analysis of adhesion, inflammatory, and migration markers, we observe that Nβ neutrophils overexpress the α4β1 integrin compared to Nα. Finally, by inhibiting α4β1 integrin, we increase the Nβ/Nα ratio and enhance CD8 T-cell responses to HIV VACV-delivered antigens. These findings provide significant advancements in the comprehension of neutrophil-based control of adaptive immune system and their relevance in vaccine design.

scholarly journals Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses

2019 ◽  
Vol 9 (6) ◽  
pp. 1095-1105 ◽  
Author(s):  
Qiuqiang Chen ◽  
Ying Bao ◽  
Danielle Burner ◽  
Sharmeela Kaushal ◽  
Yu Zhang ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Tumor Growth ◽  
Growth Inhibition ◽  
Cd8 T Cell ◽  
Tumor Growth Inhibition ◽  
T Cell Immune Responses

scholarly journals Differential Regulation of Primary and Memory CD8 T Cell Immune Responses by Diacylglycerol Kinases

2012 ◽  
Vol 188 (5) ◽  
pp. 2111-2117 ◽  
Author(s):  
Jinwook Shin ◽  
Thomas F. O’Brien ◽  
Jason M. Grayson ◽  
Xiao-Ping Zhong
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Cd8 T Cell ◽  
Differential Regulation ◽  
T Cell Immune Responses ◽  
Memory Cd8 T Cell

scholarly journals Enhanced CD8+T Cell Immune Responses and Protection Elicited againstPlasmodium bergheiMalaria by Prime Boost Immunization Regimens Using a Novel Attenuated Fowlpox Virus

2004 ◽  
Vol 172 (5) ◽  
pp. 3094-3100 ◽  
Author(s):  
Richard J. Anderson ◽  
Carolyn M. Hannan ◽  
Sarah C. Gilbert ◽  
Stephen M. Laidlaw ◽  
Eric G. Sheu ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Cd8 T Cell ◽  
Fowlpox Virus ◽  
Boost Immunization ◽  
T Cell Immune Responses

scholarly journals Antiretroviral Agents Restore Mycobacterium-Specific T-Cell Immune Responses and Facilitate Controlling a Fatal Tuberculosis-Like Disease in Macaques Coinfected with Simian Immunodeficiency Virus andMycobacterium bovis BCG

2001 ◽  
Vol 75 (18) ◽  
pp. 8690-8696 ◽  
Author(s):  
Yun Shen ◽  
Ling Shen ◽  
Prabhat Sehgal ◽  
Dejiang Zhou ◽  
Meredith Simon ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Immune Responses ◽  
Simian Immunodeficiency Virus ◽  
Antiretroviral Treatment ◽  
Antiretroviral Agents ◽  
Purified Protein Derivative ◽  
Immunodeficiency Virus ◽  
T Cell Immune Responses

ABSTRACT The contribution of immune reconstitution following antiretroviral treatment to the prevention or treatment of human immunodeficiency virus-related primary or reactivation tuberculosis remains unknown. Macaque models of simian immunodeficiency virus-Mycobacterium bovis BCG (SIV/BCG) coinfection were employed to determine the extent to which anti-Mycobacterium tuberculosis immunity can be restored by antiretroviral therapy. Both SIV-infected macaques with active BCG reinfection and naive animals with simultaneous SIV/BCG coinfection were evaluated. The suppression of SIV replication by antiretroviral treatment resulted in control of the active BCG infection and blocked development of the fatal SIV-related tuberculosis-like disease. The resolution of this disease coincided with the restoration of BCG purified protein derivative (PPD)-specific T-cell immune responses. In contrast, macaques similarly coinfected with SIV/BCG but not receiving antiretroviral therapy had depressed PPD-specific primary and memory T-cell immune responses and died from tuberculosis-like disease. These results provide in vivo evidence that the restoration of anti-mycobacterial immunity by antiretroviral agents can improve the clinical outcome of an AIDS virus-related tuberculosis-like disease.

scholarly journals Pentoxifylline Functions As an Adjuvant In Vivo to Enhance T Cell Immune Responses by Inhibiting Activation-Induced Death

2002 ◽  
Vol 169 (8) ◽  
pp. 4262-4272 ◽  
Author(s):  
Radhakrishnan Suresh ◽  
Monika Vig ◽  
Sumeena Bhatia ◽  
Eric P. B. Goodspeed ◽  
Beena John ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
T Cell Immune Responses
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