scholarly journals Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway

2015 ◽  
Vol 34 (6) ◽  
pp. 3311-3317 ◽  
Author(s):  
LICHUAN WU ◽  
LIANGXIA GUO ◽  
YUEHUI LIANG ◽  
XU LIU ◽  
LIHE JIANG ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Lung Cancer Cells ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tsung-Teng Huang ◽  
Ying-Wei Lan ◽  
Chuan-Mu Chen ◽  
Yun-Fei Ko ◽  
David M. Ojcius ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Lung Cancer Cells ◽  
Antrodia Cinnamomea ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Anti Tumor Activity

scholarly journals Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 76116-76128 ◽  
Author(s):  
Limin Wang ◽  
Limin Cao ◽  
Huimin Wang ◽  
Boning Liu ◽  
Qicheng Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Metastatic Potential ◽  
Lung Cancer Cells ◽  
Cancer Associated Fibroblasts ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatment

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jing Du ◽  
Weiwei Chen ◽  
Lijuan Yang ◽  
Juanjuan Dai ◽  
Jiwei Guo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cell Cycle Progression ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Cycle Progression ◽  
Shh Signaling ◽  
Shh Pathway

Abstract Deregulated Sonic Hedgehog (SHH) pathway facilitates the initiation, progression, and metastasis of Non-small cell lung cancer (NSCLC), confers drug resistance and renders a therapeutic interference option to lung cancer patients with poor prognosis. In this study, we screened and evaluated the specificity of a Chinese herb Scutellariabarbata D. Don extraction (SBE) in repressing SHH signaling pathway to block NSCLC progression. Our study confirmed that aberrant activation of the SHH signal pathway conferred more proliferative and invasive phenotypes to human lung cancer cells. This study revealed that SBE specifically repressed SHH signaling pathway to interfere the SHH-mediated NSCLC progression and metastasis via arresting cell cycle progression. We also found that SBE significantly sensitized lung cancer cells to chemotherapeutic agent DDP via repressing SHH components in vitro and in vivo. Mechanistic investigations indicated that SBE transcriptionally and specifically downregulated SMO and consequently attenuated the activities of GLI1 and its downstream targets in SHH signaling pathway, which interacted with cell cycle checkpoint enzymes to arrest cell cycle progression and lead to cellular growth inhibition and migration blockade. Collectively, our results suggest SBE as a novel drug candidate for NSCLC which specifically and sensitively targets SHH signaling pathway.

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