scholarly journals Valproic acid suppresses the self-renewal and proliferation of head and neck cancer stem cells

2015 ◽  
Vol 34 (4) ◽  
pp. 2065-2071 ◽  
Author(s):  
SANG HYUK LEE ◽  
HYO JUNG NAM ◽  
HYUN JUNG KANG ◽  
TINA L. SAMUELS ◽  
NIKKI JOHNSTON ◽  
...  
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
The Self ◽  
Self Renewal

scholarly journals Head and Neck Cancer Stem Cells

2011 ◽  
Vol 91 (4) ◽  
pp. 334-340 ◽  
Author(s):  
S. Krishnamurthy ◽  
J.E. Nör
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Self Renewal ◽  
Perivascular Niche

Most cancers contain a small sub-population of cells that are endowed with self-renewal, multipotency, and a unique potential for tumor initiation. These properties are considered hallmarks of cancer stem cells. Here, we provide an overview of the field of cancer stem cells with a focus on head and neck cancers. Cancer stem cells are located in the invasive fronts of head and neck squamous cell carcinomas (HNSCC) close to blood vessels (perivascular niche). Endothelial cell-initiated signaling events are critical for the survival and self-renewal of these stem cells. Markers such as aldehyde dehydrogenase (ALDH), CD133, and CD44 have been successfully used to identify highly tumorigenic cancer stem cells in HNSCC. This review briefly describes the orosphere assay, a method for in vitro culture of undifferentiated head and neck cancer stem cells under low attachment conditions. Notably, recent evidence suggests that cancer stem cells are exquisitely resistant to conventional therapy and are the “drivers” of local recurrence and metastatic spread. The emerging understanding of the role of cancer stem cells in the pathobiology of head and neck squamous cell carcinomas might have a profound impact on the treatment paradigms for this malignancy.

scholarly journals FGFR signaling regulates resistance of head and neck cancer stem cells to cisplatin

Oncotarget ◽  
2018 ◽  
Vol 9 (38) ◽  
pp. 25148-25165 ◽  
Author(s):  
Sarah C. McDermott ◽  
Christie Rodriguez-Ramirez ◽  
Sean P. McDermott ◽  
Max S. Wicha ◽  
Jacques E. Nör
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Fgfr Signaling

scholarly journals Cancer stem cells and field cancerization of head and neck cancer - An update

2020 ◽  
Vol 9 (7) ◽  
pp. 3178
Author(s):  
Richa Bansal ◽  
BikashBishwadarshee Nayak ◽  
Shweta Bhardwaj ◽  
CN Vanajakshi ◽  
Pragyan Das ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Field Cancerization

Head and Neck Cancer Stem Cells: The Effect of HPV

2012 ◽  
Vol 147 (2_suppl) ◽  
pp. P58-P59
Author(s):  
Alice L. Tang ◽  
John H. Owen ◽  
Samantha Hauff ◽  
Jung J. Park ◽  
Carol R. Bradford ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer

Abstract 4262: Characterization and regulation of a CXCR4-expressing subpopulation in head and neck cancer stem cells

2010 ◽  
Author(s):  
Alan Kiang ◽  
Eric L. Abhold ◽  
Katherine J. Blair ◽  
Michael A. Yu ◽  
Martin Haas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer

Abstract 3378: Metformin protects head and neck cancer stem cells against DNA damage induced apoptosis

2012 ◽  
Author(s):  
Selena Z. Kuo ◽  
Thomas K. Honda ◽  
Eric L. Abhold ◽  
Jessica Wang-Rodriguez ◽  
Xabier Altuna ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dna Damage ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Induced Apoptosis

scholarly journals Head and neck cancer stem cells: The side population

2010 ◽  
Vol 121 (3) ◽  
pp. 527-533 ◽  
Author(s):  
Mark H. Tabor ◽  
Matthew R. Clay ◽  
John H. Owen ◽  
Carol R. Bradford ◽  
Thomas E. Carey ◽  
...  
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Side Population
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