scholarly journals Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells

2015 ◽  
Vol 34 (2) ◽  
pp. 1011-1016 ◽  
Author(s):  
WAN-SIK LEE ◽  
NURI KIM ◽  
YOUNG-RAN PARK ◽  
HYUNG-HOON OH ◽  
EUN MYUNG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Myeloid Cell ◽  
Human Gastric Cancer ◽  
Cell Leukemia ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition

scholarly journals MicroRNA-205 suppresses the invasion and epithelial-mesenchymal transition of human gastric cancer cells

2016 ◽  
Vol 13 (6) ◽  
pp. 4767-4773 ◽  
Author(s):  
CHANG XU ◽  
MING'E LI ◽  
LIN ZHANG ◽  
YUEYANG BI ◽  
PEIYUAN WANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition

scholarly journals MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2

2009 ◽  
Vol 20 (24) ◽  
pp. 5127-5137 ◽  
Author(s):  
Kai-Wen Hsu ◽  
Rong-Hong Hsieh ◽  
Chew-Wun Wu ◽  
Chin-Wen Chi ◽  
Yan-Hwa Wu Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Suppressive Effect ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition ◽  
Cox 2

The c-Myc promoter binding protein 1 (MBP-1) is a transcriptional suppressor of c-myc expression and involved in control of tumorigenesis. Gastric cancer is one of the most frequent neoplasms and lethal malignancies worldwide. So far, the regulatory mechanism of its aggressiveness has not been clearly characterized. Here we studied roles of MBP-1 in gastric cancer progression. We found that cell proliferation was inhibited by MBP-1 overexpression in human stomach adenocarcinoma SC-M1 cells. Colony formation, migration, and invasion abilities of SC-M1 cells were suppressed by MBP-1 overexpression but promoted by MBP-1 knockdown. Furthermore, the xenografted tumor growth of SC-M1 cells was suppressed by MBP-1 overexpression. Metastasis in lungs of mice was inhibited by MBP-1 after tail vein injection with SC-M1 cells. MBP-1 also suppressed epithelial-mesenchymal transition in SC-M1 cells. Additionally, MBP-1 bound on cyclooxygenase 2 (COX-2) promoter and downregulated COX-2 expression. The MBP-1-suppressed tumor progression in SC-M1 cells were through inhibition of COX-2 expression. MBP-1 also exerted a suppressive effect on tumor progression of other gastric cancer cells such as AGS and NUGC-3 cells. Taken together, these results suggest that MBP-1–suppressed COX-2 expression plays an important role in the inhibition of growth and progression of gastric cancer.

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