scholarly journals Patient-specific characterization of the invasiveness and proliferation of low-grade gliomas using serial MR imaging and a mathematical model of tumor growth

2015 ◽  
Vol 33 (6) ◽  
pp. 2883-2888 ◽  
Author(s):  
LEITH HATHOUT ◽  
BENJAMIN M. ELLINGSON ◽  
TIMOTHY F. CLOUGHESY ◽  
WHITNEY B. POPE
Keyword(s):  
Mathematical Model ◽  
Mr Imaging ◽  
Tumor Growth ◽  
Patient Specific ◽  
Low Grade ◽  
Low Grade Gliomas

scholarly journals Dynamics and optimal control of chemotherapy for low grade gliomas: Insights from a mathematical model

2016 ◽  
Vol 21 (6) ◽  
pp. 1895-1915 ◽  
Author(s):  
Clara Rojas ◽  
Juan Belmonte-Beitia ◽  
Víctor M. Pérez-García ◽  
Helmut Maurer
Keyword(s):  
Mathematical Model ◽  
Optimal Control ◽  
Low Grade ◽  
Low Grade Gliomas

Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age

2016 ◽  
Vol 32 (10) ◽  
pp. 1813-1822 ◽  
Author(s):  
Simona Gaudino ◽  
Rosellina Russo ◽  
Tommaso Verdolotti ◽  
Massimo Caulo ◽  
Cesare Colosimo
Keyword(s):  
Mr Imaging ◽  
Low Grade ◽  
Pediatric Age ◽  
Low Grade Gliomas

The management of incidental low-grade gliomas using magnetic resonance imaging: systematic review and optimal treatment paradigm

2011 ◽  
Vol 31 (6) ◽  
pp. E12 ◽  
Author(s):  
Ashish H. Shah ◽  
Karthik Madhavan ◽  
Deborah Heros ◽  
Daniel M. S. Raper ◽  
J. Bryan Iorgulescu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Mr Imaging ◽  
Active Surveillance ◽  
Case Series ◽  
Treatment Decisions ◽  
Low Grade ◽  
Management Options ◽  
Low Grade Gliomas ◽  
Presenting Symptoms ◽  
Radiological Evidence

Object The discovery of incidental low-grade gliomas (LGGs) on MR imaging is rare, and currently there is no existing protocol for management of these lesions. Various studies have approached the dilemma of managing patients with incidental LGGs. While some advocate surgery and radiotherapy, others reserve surgery until there is radiological evidence of growth. For neurosurgeons and radiologists, determining the course of action after routine brain imaging poses not only a medical but also an ethical dilemma. The authors conducted a systematic review of case reports and case series in hopes of enhancing the current understanding of the management options for these rare lesions. Methods A PubMed search was performed to include all relevant MR imaging studies in which management of suspected incidental LGG was reported. Comparisons were made between the surgical treatment arm and the active surveillance arm in terms of outcome, mode of discovery, reasons for treatment, and histology. Results Nine studies with 72 patients were included in this study (56 in the surgical arm and 16 in the active surveillance arm). Within the surgical arm, 49% remained deficit free after treatment, 25% showed evidence of tumor progression, 13% underwent a second treatment, and 7% died. The active surveillance group resulted in no unanticipated adverse events, with serial imaging revealing no tumor growth in all cases. Lesion regression was reported in 31% of this group. The surgical arm's mortality rate was 7% compared with 0% in the active surveillance arm. Conclusions Treatment decisions for incidental LGG should be individualized based on presenting symptoms and radiological evidence of growth. The asymptomatic patient may be monitored safely with serial MR imaging and occasionally PET scanning before treatment is initiated. In patients presenting with nonspecific symptoms or concurrent symptomatic lesions, treatment may be initiated earlier to reduce potential morbidity. All treatment decisions must be tempered by patient factors and expectations of anticipated benefit.

scholarly journals Comparison of Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging and Arterial Spin Labeling MR Imaging in Gliomas

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yuankai Lin ◽  
Jianrui Li ◽  
Zhiqiang Zhang ◽  
Qiang Xu ◽  
Zhenyu Zhou ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
White Matter ◽  
Mr Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Intravoxel Incoherent Motion ◽  
Low Grade ◽  
High Grade ◽  
Low Grade Gliomas ◽  
High Grade Gliomas

Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade gliomas and 11 low grade gliomas) underwent IVIM DWI and 3D pCASL imaging before operation; maps of fast diffusion coefficient (D∗), slow diffusion coefficient (D), fractional perfusion-related volume (f), and apparent diffusion coefficient (ADC) as well as cerebral blood flow (CBF) were calculated and then coregistered to generate the corresponding parameter values. We found CBF andD∗were higher in the high grade gliomas, whereas ADC,D, andfwere lower (allP<0.05). In differentiating the high from low grade gliomas, the maximum areas under the curves (AUC) ofD∗, CBF, and ADC were 0.857, 0.85, and 0.902, respectively. CBF was negatively correlated withfin tumor (r=-0.619,P=0.001). ADC was positively correlated withDin both tumor and white matter (r=0.887,P=0.000andr=0.824,P=0.000, resp.). There was no correlation between CBF andD∗in both tumor and white matter (P>0.05). IVIM DWI showed more efficiency than 3D pCASL but less validity than conventional DWI in differentiating the high from low grade gliomas.

Low-Grade Gliomas: Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging—Prediction of Patient Clinical Response

Radiology ◽  
2006 ◽  
Vol 238 (2) ◽  
pp. 658-667 ◽  
Author(s):  
Meng Law ◽  
Sarah Oh ◽  
James S. Babb ◽  
Edwin Wang ◽  
Matilde Inglese ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Clinical Response ◽  
Low Grade ◽  
Dynamic Susceptibility ◽  
Low Grade Gliomas ◽  
Contrast Enhanced ◽  
Perfusion Mr ◽  
Perfusion Mr Imaging

Low-Grade Gliomas: Do Changes in rCBV Measurements at Longitudinal Perfusion-weighted MR Imaging Predict Malignant Transformation?

Radiology ◽  
2008 ◽  
Vol 247 (1) ◽  
pp. 170-178 ◽  
Author(s):  
Nasuda Danchaivijitr ◽  
Adam D. Waldman ◽  
Daniel J. Tozer ◽  
Christopher E. Benton ◽  
Gisele Brasil Caseiras ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Malignant Transformation ◽  
Low Grade ◽  
Low Grade Gliomas

scholarly journals Low-Grade Gliomas in Patients with Noonan Syndrome: Case-Based Review of the Literature

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 582
Author(s):  
Mariachiara Lodi ◽  
Luigi Boccuto ◽  
Andrea Carai ◽  
Antonella Cacchione ◽  
Evelina Miele ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Noonan Syndrome ◽  
Positive Outcome ◽  
Point Of View ◽  
Optic Pathway Glioma ◽  
Glioneuronal Tumor ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Solid Malignancies

Noonan syndrome (NS) is a congenital autosomic dominant condition characterized by a variable spectrum from a clinical and genetical point of view. Germline mutations in more than ten genes involved in RAS–MAPK signal pathway have been demonstrated to cause the disease. An higher risk for leukemia and solid malignancies, including brain tumors, is related to NS. A review of the published literature concerning low grade gliomas (LGGs) in NS is presented. We described also a 13-year-old girl with NS associated with a recurrent mutation in PTPN11, who developed three different types of brain tumors, i.e., an optic pathway glioma, a glioneuronal neoplasm of the left temporal lobe and a cerebellar pilocytic astrocytoma. Molecular characterization of the glioneuronal tumor allowed to detect high levels of phosphorylated MTOR (pMTOR); therefore, a therapeutic approach based on an mTOR inhibitor (everolimus) was elected. The treatment was well tolerated and proved to be effective, leading to a stabilization of the tumor, which was surgical removed. The positive outcome of the present case suggests considering this approach for patients with RASopathies and brain tumors with hyperactivated MTOR signaling.

Cellular and molecular characterization of IDH1-mutated diffuse low grade gliomas reveals tumor heterogeneity and absence of EGFR/PDGFRα activation

Glia ◽  
2017 ◽  
Vol 66 (2) ◽  
pp. 239-255 ◽  
Author(s):  
S. Azar ◽  
N. Leventoux ◽  
C. Ripoll ◽  
V. Rigau ◽  
C. Gozé ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Tumor Heterogeneity ◽  
Low Grade ◽  
Low Grade Gliomas
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