scholarly journals Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2

2015 ◽  
Vol 33 (4) ◽  
pp. 1630-1638 ◽  
Author(s):  
QIU-YU ZHANG ◽  
LIN-QING WU ◽  
TAO ZHANG ◽  
YAN-FEI HAN ◽  
XU LIN
Keyword(s):  
Gastric Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Extracellular Signal ◽  
Cancer Cell Survival

scholarly journals The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184514 ◽  
Author(s):  
Pål Vange ◽  
Torunn Bruland ◽  
Berit Doseth ◽  
Reidar Fossmark ◽  
Mirta M. L. Sousa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Rodent Models ◽  
Cancer Cell Survival

RKIP inhibits gastric cancer cell survival and invasion by regulating the expression of HMGA2 and OPN

Tumor Biology ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 11949-11958 ◽  
Author(s):  
Hongyi Liu ◽  
Peng Li ◽  
Bing Li ◽  
Peng Sun ◽  
Jiajin Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Survival

scholarly journals Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway

2007 ◽  
Vol 46 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Tateo Sawabu ◽  
Hiroshi Seno ◽  
Tomoko Kawashima ◽  
Akihisa Fukuda ◽  
Yoshito Uenoyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Survival ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Growth Arrest ◽  
Akt Pathway ◽  
Specific Gene ◽  
Cancer Cell Survival

scholarly journals Gastric tumorigenesis induced either by Helicobacter pylori infection or chronic alcohol consumption through IL-10 inhibition

2020 ◽  
Author(s):  
Faisal Aziz ◽  
Abhijit Chakarobaty ◽  
Kandong Liu ◽  
Hisae Yoshitomi ◽  
Xiang Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Alcohol Consumption ◽  
Mitochondrial Dysfunction ◽  
Cell Survival ◽  
Cancer Cell ◽  
Molecular Mechanisms ◽  
Gastric Carcinogenesis ◽  
Cd8 Cells ◽  
Cancer Cell Survival ◽  
H Pylori

Abstract Background Alcohol is class 1 carcinogen and results in 3.3 million deaths every year. H. pylori is also an important factor for gastric carcinogen. Alcohol consumption is emerging as an important contributor to gastric cancer, but there is no direct or experimental evidence of alcohol and H. pylori infection produce gastric cancer in human and animal model alone. Here, we provide insight into the molecular mechanisms driving gastric carcinogenesis. Results Alcohol consumption, together with H. pylori infection, causes gastric cancer; interleukin-10 (IL-10) downregulation and mitochondrial metabolic dysfunction in CD8+ cells are also involved. IL-10 knockout accelerates tumor development in mice with either H. pylori infection or alcohol induced gastric cancer or both. IL-10 downregulation and CD-8+ cell dysfunction stimulates IL-1β secretion. Specifically, we show IL-10 inhibits glucose uptake and glycolysis and promotes oxidative phosphorylation with lactate inhibition. Consequently, In the absence of IL-10 signaling, CD8+ cells accumulate damaged mitochondria in a mouse model of gastric cancer induced with the combination of alcohol plus H. pylori infection, and this results in mitochondrial dysfunction and production of IL-1 β. IL-1β promotes H. pylori infection and reduces NKX6.3 gene expression, resulting in increased cancer cell survival and proliferation. Conclusions Overall, the molecular mechanisms of gastric carcinogenesis include IL-10 inhibition resulting in lowered host immunity via mitochondrial dysfunction of CD8+ lymphocytes; gastric inflammation due to H. pylori infection, alcohol intake, and IL-1β production; and disruption of gastric-specific tumor suppressor NKX6.3 expression, which increases cancer cell survival and proliferation.

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