scholarly journals Establishment of a Langerhans cell histiocytosis lesion cell line with dermal dendritic cell characteristics

2014 ◽  
Vol 33 (1) ◽  
pp. 171-178 ◽  
Author(s):  
ICHIRO MURAKAMI ◽  
JEAN GOGUSEV ◽  
FRANCIS JAUBERT ◽  
MICHIKO MATSUSHITA ◽  
KAZUHIKO HAYASHI ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Cell Line ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Dermal Dendritic Cell

Establishment of cell line and in vivo mouse model of canine Langerhans cell histiocytosis

2019 ◽  
Vol 17 (3) ◽  
pp. 345-353 ◽  
Author(s):  
Nguyen V. Son ◽  
Kazuyuki Uchida ◽  
Atigan Thongtharb ◽  
James K. Chambers ◽  
Takuya E. Kishimoto ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cell Line ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell

Langerhans cell histiocytosis: fascinating dynamics of the dendritic cell-macrophage lineage

2010 ◽  
Vol 234 (1) ◽  
pp. 213-232 ◽  
Author(s):  
R. Maarten Egeler ◽  
Astrid G. S. van Halteren ◽  
Pancras C. W. Hogendoorn ◽  
Jon D. Laman ◽  
Pieter J. M. Leenen
Keyword(s):  
Dendritic Cell ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Macrophage Lineage

Normal monocyte-derived dendritic cell function in patients with langerhans-cell-histiocytosis

2002 ◽  
Vol 39 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Wolfgang Holter ◽  
Gabriele Ressmann ◽  
Nicole Grois ◽  
Manfred Lehner ◽  
Ornella Parolini ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Langerhans Cell Histiocytosis ◽  
Cell Function ◽  
Langerhans Cell ◽  
Dendritic Cell Function ◽  
Normal Monocyte

scholarly journals A CD34+human cell line model of myeloid dendritic cell differentiation: evidence for a CD14+CD11b+Langerhans cell precursor

2006 ◽  
Vol 80 (6) ◽  
pp. 1337-1344 ◽  
Author(s):  
Saskia J. A. M. Santegoets ◽  
Allan J. Masterson ◽  
Pieter C. van der Sluis ◽  
Sinéad M. Lougheed ◽  
Donna M. Fluitsma ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Dendritic Cell ◽  
Cell Line ◽  
Human Cell ◽  
Human Cell Line ◽  
Langerhans Cell ◽  
Myeloid Dendritic Cell ◽  
Cell Precursor ◽  
Dendritic Cell Differentiation ◽  
Cell Line Model

Langerhans Cell Histiocytosis: Back to Histiocytosis X

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. SCI-8-SCI-8
Author(s):  
Carl E. Allen
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Langerhans Cells ◽  
Langerhans Cell Histiocytosis ◽  
Conflicts Of Interest ◽  
Langerhans Cell ◽  
Histiocytosis X ◽  
Specific Gene ◽  
Myeloid Dendritic Cell ◽  
Epidermal Langerhans Cells

Abstract Abstract SCI-8 Langerhans cell histiocytosis (LCH) is a disorder characterized by inflammatory lesions that include pathologic CD207+ dendritic cells. LCH has pleotropic clinical presentations ranging from single lesions cured by curettage to potentially fatal multisystem disease. The first descriptions of LCH, including Hand-Schüller-Christian disease and Letterer-Siwe disease, were based on anatomic location and extent of the lesions. Despite clinical heterogeneity, LCH lesions are generally indistinguishable by histology, which led to the notion that the spectrum of clinical manifestations represents a single disorder, histiocytosis X. The designation “Langerhans cell histiocytosis” was subsequently proposed with discovery of cytoplasmic Birbeck granules in the pathologic infiltrating dendritic cells in histiocytosis X lesions, a feature shared by epidermal Langerhans cells. The etiology of LCH remains elusive, and debate of LCH as an inflammatory versus malignant disorder remains unresolved. However, recent discoveries question the model of LCH arising from transformed or pathologically activated epidermal Langerhans cells. We found cell-specific gene expression signature in CD207+ dendritic cells within LCH lesions to be more consistent with immature myeloid dendritic cell precursors than epidermal Langerhans cells. Furthermore, recent mouse studies demonstrate that CD207+ is more promiscuous than previously appreciated. Langerin (CD207) expression can be induced in many dendritic cell lineages, supporting the plausibility of a spectrum of candidates for an LCH cell of origin, including circulating dendritic cell precursors. Finally, recurrent activating BRAF mutations in LCH lesions suggest a role for a hyperactive RAS pathway in LCH pathogenesis, and possibly in normal dendritic cell development. This presentation will discuss the historical background and recent advances in LCH biology, along with a proposal to reframe “histiocytosis X” as a myeloid neoplasia caused by aberrant maturation and migration of myeloid dendritic cell precursors. Disclosures: No relevant conflicts of interest to declare.

DOR-1, A novel CD10+ stromal cell line derived from progressive Langerhans cell histiocytosis of bone

2005 ◽  
Vol 44 (2) ◽  
pp. 128-137 ◽  
Author(s):  
Jean Gogusev ◽  
Louise Telvi ◽  
Ichiro Murakami ◽  
Yves Lepelletier ◽  
Christian Nezelof ◽  
...  
Keyword(s):  
Cell Line ◽  
Langerhans Cell Histiocytosis ◽  
Stromal Cell ◽  
Langerhans Cell ◽  
Stromal Cell Line

Lymphomatoid papulosis with CD1a+ dendritic cell hyperplasia, mimicking Langerhans cell histiocytosis

2007 ◽  
Vol 34 (7) ◽  
pp. 584-587 ◽  
Author(s):  
Chris H. Jokinen ◽  
Gregory M. Wolgamot ◽  
Brent L. Wood ◽  
John Olerud ◽  
Zsolt B. Argenyi
Keyword(s):  
Dendritic Cell ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Cell Hyperplasia ◽  
Lymphomatoid Papulosis
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