scholarly journals Allelic loss at chromosome 11q13 alters FGF3 gene expression in a human breast cancer progression model

2014 ◽  
Vol 32 (6) ◽  
pp. 2445-2452 ◽  
Author(s):  
DEBASISH ROY ◽  
GLORIA M. CALAF
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Allelic Loss ◽  
Human Breast ◽  
Chromosome 11Q13 ◽  
Progression Model

Increased production and secretion of HGF α-chain and an antagonistic HGF fragment in a human breast cancer progression model

2009 ◽  
Vol 125 (5) ◽  
pp. 1004-1015 ◽  
Author(s):  
Theodore G. Wright ◽  
Vinay K. Singh ◽  
John J. Li ◽  
Jonathan H. Foley ◽  
Fred Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Human Breast ◽  
Progression Model ◽  
Α Chain

scholarly journals Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression

2004 ◽  
Vol 6 (5) ◽  
Author(s):  
Martin C Abba ◽  
Jeffrey A Drake ◽  
Kathleen A Hawkins ◽  
Yuhui Hu ◽  
Hongxia Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Human Breast ◽  
Transcriptomic Changes

scholarly journals Gene expression profiles of human breast cancer progression

2003 ◽  
Vol 100 (10) ◽  
pp. 5974-5979 ◽  
Author(s):  
X.-J. Ma ◽  
R. Salunga ◽  
J. T. Tuggle ◽  
J. Gaudet ◽  
E. Enright ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Breast Cancer Progression ◽  
Human Breast

scholarly journals Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers

2012 ◽  
Vol 72 (9) ◽  
pp. 2428-2439 ◽  
Author(s):  
Tamar Geiger ◽  
Stephen F. Madden ◽  
William M. Gallagher ◽  
Juergen Cox ◽  
Matthias Mann
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Breast Cancer Progression ◽  
Human Breast

scholarly journals Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 29 ◽  
Author(s):  
Jyun-Yuan Huang ◽  
Yen-Yun Wang ◽  
Steven Lo ◽  
Ling-Ming Tseng ◽  
Dar-Ren Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Breast Cancer Progression ◽  
Akt Pathway ◽  
Adipose Derived Stem Cells ◽  
Human Breast ◽  
Akt Inhibitor ◽  
Promoting Effect

Adipose-derived stem cells (ADSCs) have been implicated in tumor growth and metastasis in breast cancer. ADSCs exhibit tumor tropism, and are of increasing clinical relevance due to the autologous fat grafting for breast reconstruction. Although we have previously shown that a high level of the adipocytokine visfatin in human breast cancer tissues correlated with tumor progression mediated by cAbl and STAT3, the effects of visfatin in the tumor microenvironment are unclear. To understand how visfatin modulates breast cancer within the tumor-stromal environment, we examined determinants of breast cancer progression using a visfatin-primed ADSCs-tumor co-culture model. ADSCs were isolated from tumor-free adipose tissue adjacent to breast tumors. ADSCs were treated with or without visfatin for 48 h and then collected for co-culture with breast cancer cell line MDA-MB-231 for 72 h in a transwell system. We found that the MDA-MB-231 cells co-cultured with visfatin-treated ADSCs (vADSCs) had higher levels of cell viability, anchorage independent growth, migration, invasion, and tumorsphere formation than that co-cultured with untreated ADSCs (uADSCs). Growth differentiation factor 15 (GDF15) upregulation was found in the co-culture conditioned medium, with GDF15 neutralizing antibody blocking the promoting effect on MDA-MB-231 in co-culture. In addition, a GDF15-induced AKT pathway was found in MDA-MB-231 and treatment with PI3K/AKT inhibitor also reversed the promoting effect. In an orthotopic xenograft mouse model, MDA-MB-231 co-injected with vADSCs formed a larger tumor mass than with uADSCs. Positive correlations were noted between visfatin, GDF15, and phosphor-AKT expressions in human breast cancer specimens. In conclusion, visfatin activated GDF15-AKT pathway mediated via ADSCs to facilitate breast cancer progression.

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