scholarly journals Minocycline and cisplatin exert synergistic growth suppression on hepatocellular carcinoma by inducing S phase arrest and apoptosis

2014 ◽  
Vol 32 (2) ◽  
pp. 835-844 ◽  
Author(s):  
FU-YAO LIU ◽  
AN-HUI WU ◽  
SHAO-JUN ZHOU ◽  
YUE-LING DENG ◽  
ZUN-YI ZHANG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Suppression ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Antitumor Effect of Pyrogallol via miR-134 Mediated S Phase Arrest and Inhibition of PI3K/AKT/Skp2/cMyc Signaling in Hepatocellular Carcinoma

2019 ◽  
Vol 20 (16) ◽  
pp. 3985 ◽  
Author(s):  
Hyojin Ahn ◽  
Eunji Im ◽  
Dae Young Lee ◽  
Hyo-Jung Lee ◽  
Ji Hoon Jung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Expression ◽  
Cyclin E ◽  
S Phase ◽  
Carcinoma Cells ◽  
Antitumor Effects ◽  
Colon Cancers ◽  
Phase Arrest ◽  
Huh7 Cells ◽  
S Phase Arrest

Though Pyrogallol, one of the natural polyphenols, was known to have anti-inflammatory and antitumor effects in breast and colon cancers, the underlying antitumor mechanisms of Pyrogallol, still remain unclear so far. Here, the antitumor mechanisms of Pyrogallol were elucidated in Hep3B and Huh7 hepatocellular carcinoma cells (HCCs). Pyrogallol showed significant cytotoxicity and reduced the number of colonies in Hep3B and Huh7 cells. Interestingly, Pyrogallol induced S-phase arrest and attenuated the protein expression of CyclinD1, Cyclin E, Cyclin A, c-Myc, S-phase kinase-associated protein 2 (Skp2), p-AKT, PI3K, increased the protein expression of p27, and also reduced the fluorescent expression of Cyclin E in Hep3B and Huh7 cells. Furthermore, Pyrogallol disturbed the interaction between Skp2, p27, and c-Myc in Huh7 cells. Notably, Pyrogallol upregulated miRNA levels of miR-134, and conversely, miR-134 inhibition rescued the decreased expression levels of c-Myc, Cyclin E, and Cyclin D1 and increased the expression of p27 by Pyrogallol in Huh7 cells. Taken together, our findings provide insight that Pyrogallol exerts antitumor effects in HCCs via miR-134 activation-mediated S-phase arrest and inhibition of PI3K/AKT/Skp2/cMyc signaling as a potent anticancer candidate.

scholarly journals Ku80 functions as a tumor suppressor in hepatocellular carcinoma by inducing S-phase arrest through a p53-dependent pathway

2012 ◽  
Vol 33 (3) ◽  
pp. 538-547 ◽  
Author(s):  
Shuang Wei ◽  
Min Xiong ◽  
Da-qian Zhan ◽  
Bin-yong Liang ◽  
Yang-yang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Suppressor ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
Dependent Pathway

scholarly journals Expression of 1N3R-Tau Isoform Inhibits Cell Proliferation by Inducing S Phase Arrest in N2a Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119865 ◽  
Author(s):  
Li Li ◽  
Zhi-Peng Xu ◽  
Gong-Ping Liu ◽  
Cheng Xu ◽  
Zhi-Hao Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
S Phase ◽  
Phase Arrest ◽  
N2a Cells ◽  
S Phase Arrest ◽  
Tau Isoform
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