scholarly journals Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells

2014 ◽  
Vol 31 (5) ◽  
pp. 2181-2186 ◽  
Author(s):  
JUNJIE LI ◽  
RUILEI LIU ◽  
YE YANG ◽  
YONG HUANG ◽  
XI LI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
In Vivo Cytotoxicity

Effects of an mTOR inhibitor RAD001 on human breast cancer stem cells in vitro and in vivo.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e11514-e11514 ◽  
Author(s):  
J. Zhang ◽  
X. b. Zhang ◽  
Y. Liu ◽  
J. j. Liu ◽  
Y. Ma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Mtor Inhibitor ◽  
Breast Cancer Stem Cells ◽  
Human Breast

Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo

Tumor Biology ◽  
2012 ◽  
Vol 33 (5) ◽  
pp. 1349-1362 ◽  
Author(s):  
Yuanxi Zhu ◽  
Xiaobei Zhang ◽  
Yan Liu ◽  
Sheng Zhang ◽  
Jingjing Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Antitumor Effect ◽  
Mtor Inhibitor ◽  
Breast Cancer Stem Cells ◽  
Human Breast

scholarly journals Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo

2009 ◽  
Vol 280 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Rie Ayuzawa ◽  
Chiyo Doi ◽  
Raja Shekar Rachakatla ◽  
Marla M. Pyle ◽  
Dharmendra Kumar Maurya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Umbilical Cord ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Umbilical Cord Matrix

scholarly journals Repurposing of Fluvastatin as an Anticancer Agent against Breast Cancer Stem Cells via Encapsulation in a Hyaluronan-Conjugated Liposome

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1133
Author(s):  
Ji Yu ◽  
Dae Shin ◽  
Jin-Seok Kim
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Body Weight Loss ◽  
Breast Cancer Stem Cells ◽  
Anticancer Efficacy

Fluvastatin (FLUVA), which is a common anti-hypercholesterolemia drug, exhibits potential anticancer activity as it suppresses the proliferation, angiogenesis, and metastasis of breast cancer cells via inhibiting 3-hydroxy-methyl glutaryl-coenzyme A (HMG-CoA) reductase. In this study, hyaluronan-conjugated FLUVA-encapsulating liposomes (HA-L-FLUVA) were evaluated for their anticancer efficacy in vitro and in vivo. The particle size, zeta potential, and encapsulation efficiency of HA-L-FLUVA were 158.36 ± 1.78 nm, −24.85 ± 6.26 mV, and 35%, respectively. Growth inhibition of breast cancer stem cells (BCSCs) by HA-L-FLUVA was more effective than that by free FLUVA. The half maximal inhibitory concentration (IC50) values of FLUVA, L-FLVUA, and HA-L-FLUVA were 0.16, 0.17, and 0.09 μM, respectively. The in vivo anticancer effect of HA-L-FLUVA in combination with doxorubicin (DOX) was more effective than that of free FLUVA, free DOX, and HA-L-FLUVA. The longest survival of mice was achieved by treatment with FLUVA (15 mg/kg) and HA-L-FLUVA (15 mg/kg) + DOX (3 mg/kg), followed by HA-L-FLUVA (15 mg/kg), Dulbecco’s phosphate buffered saline, and DOX (3 mg/kg). No more than 10% body weight loss was observed in the mice injected with FLUVA, indicating that the drug was not toxic. Taken together, these results indicate that HA-L-FLUVA could serve as an effective anticancer drug by inhibiting the growth of both breast cancer cells and cancer stem cells.

scholarly journals Correction: In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247694
Author(s):  
Septelia Inawati Wanandi ◽  
Agus Limanto ◽  
Elvira Yunita ◽  
Resda Akhra Syahrani ◽  
Melva Louisa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
In Silico ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Phosphosulindac (OXT-328) Selectively Targets Breast Cancer Stem Cells In Vitro and in Human Breast Cancer Xenografts

Stem Cells ◽  
2012 ◽  
Vol 30 (10) ◽  
pp. 2065-2075 ◽  
Author(s):  
Caihua Zhu ◽  
Ka-Wing Cheng ◽  
Nengtai Ouyang ◽  
Liqun Huang ◽  
Yu Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Breast Cancer Xenografts

scholarly journals Mutant TNF-α negatively regulates human breast cancer stem cells from MCF7 in vitro

2007 ◽  
Vol 6 (9) ◽  
pp. 1476-1485 ◽  
Author(s):  
Yaochen Li ◽  
Linghong Kong ◽  
Ye Yang ◽  
Kangsheng Li
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast ◽  
Tnf Α

scholarly journals CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

2010 ◽  
Vol 120 (2) ◽  
pp. 485-497 ◽  
Author(s):  
Christophe Ginestier ◽  
Suling Liu ◽  
Mark E. Diebel ◽  
Hasan Korkaya ◽  
Ming Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Stem Cells ◽  
Human Breast
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