scholarly journals Overexpression of CENP-H as a novel prognostic biomarker for human hepatocellular carcinoma progression and patient survival

2013 ◽  
Vol 30 (5) ◽  
pp. 2238-2244 ◽  
Author(s):  
GUIFANG LU ◽  
TAO SHAN ◽  
SHUIXIANG HE ◽  
MUDAN REN ◽  
MENG ZHU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Patient Survival ◽  
Prognostic Biomarker ◽  
Human Hepatocellular Carcinoma

scholarly journals FOXC2 is a prognostic biomarker and contributes to the growth and invasion of human hepatocellular carcinoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jinzhang Chen ◽  
Xiaoxiang Rong ◽  
Xinhui Liu ◽  
Dayong Zheng ◽  
Xiaodong Rong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Biomarker ◽  
Human Hepatocellular Carcinoma

Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma

2012 ◽  
Vol 14 (4) ◽  
pp. 287-293 ◽  
Author(s):  
Jeng-Wei Lu ◽  
Jan-Gowth Chang ◽  
Kun-Tu Yeh ◽  
Rong-Ming Chen ◽  
Jeffrey J. P. Tsai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Patient Survival ◽  
Human Hepatocellular Carcinoma

A low level of GPR37 is associated with human hepatocellular carcinoma progression and poor patient survival

2014 ◽  
Vol 210 (12) ◽  
pp. 885-892 ◽  
Author(s):  
Fang Liu ◽  
Changlai Zhu ◽  
Xiaodong Huang ◽  
Jing Cai ◽  
Hua Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Patient Survival ◽  
Human Hepatocellular Carcinoma ◽  
Low Level ◽  
Poor Patient ◽  
Poor Patient Survival

scholarly journals Centromere Protein F (CENPF) Serves as a Potential Prognostic Biomarker and Target for Human Hepatocellular Carcinoma

2021 ◽  
Vol 12 (10) ◽  
pp. 2933-2951
Author(s):  
Yugang Huang ◽  
Xiuwen Chen ◽  
Li Wang ◽  
Tieyan Wang ◽  
Xianbin Tang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Biomarker ◽  
Human Hepatocellular Carcinoma ◽  
Centromere Protein ◽  
Protein F

scholarly journals Erythropoietin as a Potential Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Huange Zhu ◽  
Yanping Zhang ◽  
Jiafeng Yin ◽  
Jie Lu ◽  
Hailong Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatocellular Carcinoma ◽  
Immune Checkpoint ◽  
Immune Cell ◽  
Patient Survival ◽  
Prognostic Biomarker ◽  
Immune Cell Infiltration ◽  
Checkpoint Gene ◽  
Immune Infiltration ◽  
Cancer Types

Abstract Background. Hepatocellular carcinoma (HCC) is a malignant tumor with poor prognosis. Immune checkpoint genes are considered novel tumor immunotherapy targets for many cancer types. Erythropoietin (EPO) is a protein secreted mainly in the liver and kidneys; in several cancer types, EPO expression stimulates tumor growth and corelates with patient survival. The study aimed to identify EPO as a prognostic biomarker correlated with immune infiltration in HCC. Methods. We investigated the correlation between EPO expression and HCC patient clinical characteristics using data from The Cancer Genome Atlas. The relationship between EPO expression and HCC patient survival was investigated using Kaplan–Meier analysis. We also used R (v.3.6.3) to analyze the correlation between EPO expression and immune infiltration in HCC. Results. We found that EPO expression was downregulated in HCC. Notably, EPO was upregulated in advanced-stage HCC and had a diagnostic value of 0.83 (p < 0.001) in HCC diagnosis. HCC patients with increased EPO expression had poor prognoses. Furthermore, altered EPO expression was associated with immune cell infiltration and immune checkpoint gene expression in HCC. Conclusions. EPO expression was positively correlated with hepatocellular carcinoma stage, and negatively correlated with patient prognosis, with influening HCC immune cell infiltration and checkpoint gene expression. EPO can be as both a potential prognostic biomarker and a novel potential treatment target for HCC.Our work is not a clinical trial, but preclinical basic study.

scholarly journals HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Feng Xue ◽  
Brandon W. Higgs ◽  
Jiaqi Huang ◽  
Chris Morehouse ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplant ◽  
Prognostic Biomarker ◽  
Human Hepatocellular Carcinoma
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