scholarly journals Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma

2013 ◽  
Vol 29 (6) ◽  
pp. 2147-2153 ◽  
Author(s):  
KAHORI SETO ◽  
JUNICHI SHODA ◽  
TOMOHISA HORIBE ◽  
EIJI WARABI ◽  
KAZUNORI ISHIGE ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Antitumor Activity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Interleukin 4 ◽  
Hybrid Peptide ◽  
Interleukin 4 Receptor

Serum levels of interleukins 4 and 10 in head and neck squamous cell carcinoma

2011 ◽  
Vol 126 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Z Mojtahedi ◽  
B Khademi ◽  
A Yehya ◽  
A Talebi ◽  
M J Fattahi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumour Progression ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Neck Squamous Cell Carcinoma ◽  
Interleukin 4 ◽  
Tumour Stage

AbstractObjective:There is currently controversy over the association between serum interleukin-4 and -10 levels and head and neck squamous cell carcinoma in patients of different ethnicity. This study aimed to investigate serum levels of these cytokines in Iranian patients with this pathology, and to analyse correlations with tumour location and tumour stage at diagnosis.Design:Serum cytokines levels were quantified using commercial enzyme-linked immunosorbent assays.Subjects:Study groups comprised 93 untreated patients and 53 healthy donors.Results:Serum interleukin-4 levels were significantly increased in patients compared with controls (p < 0.000), but were not significantly associated with tumour stage. Serum interleukin-10 levels were not raised in patients, nor associated with tumour stage.Conclusion:Serum levels of interleukin-4, but not -10, were increased in Iranian head and neck squamous cell carcinoma patients. These data do not support an association of these cytokines with tumour progression; this is consistent with previous findings.

scholarly journals Association of Inflammation-Related Gene Polymorphisms With Susceptibility and Radiotherapy Sensitivity in Head and Neck Squamous Cell Carcinoma Patients in Northeast China

2021 ◽  
Vol 11 ◽  
Author(s):  
Ying Li ◽  
Li Zhu ◽  
Hongmin Yao ◽  
Ye Zhang ◽  
Xiangyu Kong ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Gene Polymorphisms ◽  
Neck Squamous Cell Carcinoma ◽  
Interleukin 4 ◽  
Related Gene ◽  
Dominance Model ◽  
Increased Risk

BackgroundInflammation-related gene polymorphisms are some of the most important determinants for cancer susceptibility, clinical phenotype diversity, and the response to radiotherapy and chemotherapy. However, the relationship between these polymorphisms and head and neck squamous cell carcinoma (HNSCC) remains unclear. The aim of this study was to investigate the role of inflammation-related gene polymorphisms in the developmental risk and radiotherapy sensitivity of HNSCC.MethodsThe Matrix-Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) genotyping system was used to genotype 612 individuals from a Chinese population for 28 inflammation-related gene polymorphisms.ResultsThe protein kinase B (AKT1) rs1130233 TT, dominance model (CT+TT vs. CC), recessive model (TT vs. CT+CC), and rs2494732 CC genotypes were associated with reduced risk of HNSCC (P=0.014; P=0.041; P=0.043). The polymeric immunoglobulin receptor (PIGR) rs291097 GA, dominance model (GA+AA vs. GG), and rs291102 dominance model (GA+AA vs. GG) were associated with increased risk of HNSCC (P=0.025; P=0.025; P=0.040). The interleukin-4 receptor-α (IL-4RA) rs1801275 AA genotype was significantly correlated with increased radiotherapy sensitivity of HNSCC patients (P=0.030). In addition, age ≤ 60 years, non-smoker status, and normal levels of squamous cell carcinoma antigen (SCC) were found to be associated with increased radiotherapy sensitivity of HNSCC patients (P=0.033; P=0.033; P=0.030).ConclusionThe AKT1 rs1130233, AKT1 rs2494732, PIGR rs291097, and PIGR rs291102 polymorphisms were significantly related to the risk of HNSCC. The IL-4RA rs1801275 polymorphism, age ≤ 60 years, non-smoker status, and normal levels of SCC were significantly associated with increased radiotherapy sensitivity of HNSCC.

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