scholarly journals Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation

2012 ◽  
Vol 28 (5) ◽  
pp. 1574-1578 ◽  
Author(s):  
NAOTO SATO ◽  
YASUSHI SAGA ◽  
HIROAKI MIZUKAMI ◽  
DONGDONG WANG ◽  
SUZUYO TAKAHASHI ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Natural Killer Cell ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Natural Killer ◽  
Killer Cell ◽  
Indoleamine 2,3 Dioxygenase ◽  
Cell Accumulation ◽  
Cervical Cancer Cells

A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity

Life Sciences ◽  
2021 ◽  
Vol 277 ◽  
pp. 119438
Author(s):  
Chin-Cheng Lee ◽  
Kuo-Hao Ho ◽  
Tzu-Wen Huang ◽  
Chwen-Ming Shih ◽  
Shao-Yuan Hsu ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Cancer Cells ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Cytotoxicity ◽  
Natural Killer Cell Cytotoxicity ◽  
Regulatory Loop

scholarly journals Upregulation of Long Non-Coding RNA Small Nucleolar RNA Host Gene 12 Contributes to Cell Growth and Invasion in Cervical Cancer by Acting as a Sponge for MiR-424-5p

2018 ◽  
Vol 45 (5) ◽  
pp. 2086-2094 ◽  
Author(s):  
Jing Dong ◽  
Qing Wang ◽  
Li Li ◽  
Zhang Xiao-jin
Keyword(s):  
Cervical Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Host Gene ◽  
Migration And Invasion ◽  
Small Nucleolar Rna ◽  
Cervical Cancer Cells ◽  
Cancer Tissues ◽  
Nucleolar Rna

Background/Aims: Cervical cancer, which is one of the most aggressive cancers affecting females, has high rates of recurrence and mortality. Small nucleolar RNA host gene 12 (SNHG12) is known to promote the progression of several cancers; however, its exact effects and molecular mechanisms in cervical cancer remain unknown. Methods: Real-time quantitative PCR was used to determine the expression level of SNHG12 in cervical cancer tissues and cell lines. Loss-of-function assays were performed to examine the effect of SNHG12 on the proliferation, apoptosis, migration and invasion of cervical cancer cells in vitro and tumor growth in vivo. Luciferase experiments were employed to explore the interactions between SNHG12 and miR-424-5p. Results: SNHG12 was found to be abnormally elevated in human cervical cancer tissues compared with paired adjacent normal tissues. Moreover, high SNHG12 expression in tumor tissues was significantly correlated with vascular involvement, lymph node metastasis, advanced FIGO stage and poor prognosis. Furthermore, the knockdown of SNHG12 was found to inhibit proliferation, migration and invasion of cervical cancer cells in vitro, and silencing SNHG12 was shown to suppress tumor growth in a nude mouse model. Mechanistic studies showed that SNHG12 functioned as an endogenous sponge for miR-424-5p, thereby downregulating the expression of miR-424-5p in cervical cancer. Furthermore, the inhibition of miR-424-5p in SNHG12-depleted cells partially reversed the effects on cervical cancer cell apoptosis, adhesion and invasion. Conclusion: In summary, our findings suggest that the tumor-promoting role of SNHG12 is to function as a molecular sponge, which negatively regulates miR-424-5p. These findings may provide a potent therapeutic target for cervical cancer.

scholarly journals VERU-111 suppresses tumor growth and metastatic phenotypes of cervical cancer cells through the activation of p53 signaling pathway

2020 ◽  
Vol 470 ◽  
pp. 64-74 ◽  
Author(s):  
Vivek K. Kashyap ◽  
Nirnoy Dan ◽  
Neeraj Chauhan ◽  
Qinghui Wang ◽  
Saini Setua ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
P53 Signaling ◽  
Cervical Cancer Cells ◽  
P53 Signaling Pathway

Cell-Membrane Immunotherapy Based on Natural Killer Cell Membrane Coated Nanoparticles for the Effective Inhibition of Primary and Abscopal Tumor Growth

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12096-12108 ◽  
Author(s):  
Guanjun Deng ◽  
Zhihong Sun ◽  
Sanpeng Li ◽  
Xinghua Peng ◽  
Wenjun Li ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Cell Membrane ◽  
Tumor Growth ◽  
Natural Killer ◽  
Killer Cell ◽  
Coated Nanoparticles ◽  
Effective Inhibition

B7-1 Enhances Natural Killer Cell-Mediated Cytotoxicity and Inhibits Tumor Growth of a Poorly Immunogenic Murine Carcinoma

1995 ◽  
Vol 165 (2) ◽  
pp. 217-224 ◽  
Author(s):  
Kun-Yun Yeh ◽  
Beth A. Pulaski ◽  
Melody L. Woods ◽  
Alexander J. McAdam ◽  
Anthony A. Gaspari ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Tumor Growth ◽  
Natural Killer ◽  
Killer Cell
Sign in / Sign up

Export Citation Format

Share Document