scholarly journals Phosphoprotein associated with glycosphingolipid microdomains 1 inhibits the proliferation and invasion of human prostate cancer cells in vitro through suppression of Ras activation

2012 ◽  
Vol 28 (2) ◽  
pp. 606-614 ◽  
Author(s):  
WENJUAN YU ◽  
YUEWEI WANG ◽  
MIAOZI GONG ◽  
FEI PEI ◽  
JIE ZHENG
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Ras Activation ◽  
Proliferation And Invasion

Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells

2005 ◽  
Vol 83 (5) ◽  
pp. 637-643 ◽  
Author(s):  
Michael D Matchett ◽  
Shawna L MacKinnon ◽  
Marva I Sweeney ◽  
Katherine T Gottschall-Pass ◽  
Robert A.R Hurta
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Human Prostate ◽  
Response To Treatment ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
The Matrix ◽  
Ecm Degradation

Regulation of the matrix metalloproteinases (MMPs), the major mediators of extracellular matrix (ECM) degradation, is crucial to regulate ECM proteolysis, which is important in metastasis. This study examined the effects of 3 flavonoid-enriched fractions (a crude fraction, an anthocyanin-enriched fraction, and a proanthocyanidin-enriched fraction), which were prepared from lowbush blueberries (Vaccinium angustifolium), on MMP activity in DU145 human prostate cancer cells in vitro. Using gelatin gel electrophoresis, MMP activity was evaluated from cells after 24-hr exposure to blueberry fractions. All fractions elicited an ability to decrease the activity of MMP-2 and MMP-9. Of the fractions tested, the proanthocyanidin-enriched fraction was found to be the most effective at inhibiting MMP activity in these cells. No induction of either necrotic or apoptotic cell death was noted in these cells in response to treatment with the blueberry fractions. These findings indicate that flavonoids from blueberry possess the ability to effectively decrease MMP activity, which may decrease overall ECM degradation. This ability may be important in controlling tumor metastasis formation.Key words: blueberry flavonoids, MMP activity, prostate cancer cells.

scholarly journals MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10147 ◽  
Author(s):  
Qingchuan Dong ◽  
Ping Meng ◽  
Tao Wang ◽  
Weiwei Qin ◽  
Weijun Qin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

In vivo and in vitro studies of anticancer actions of α-TEA for human prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (8) ◽  
pp. 849-860 ◽  
Author(s):  
Li Jia ◽  
Weiping Yu ◽  
Pei Wang ◽  
Bob G. Sanders ◽  
Kimberly Kline
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
In Vitro Studies ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells
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