scholarly journals Correlation of the risk of breast cancer and disruption of the circadian rhythm (Review)

2012 ◽  
Vol 28 (2) ◽  
pp. 418-428 ◽  
Author(s):  
GIULIA COSTANZA LEONARDI ◽  
VENERANDO RAPISARDA ◽  
ANDREA MARCONI ◽  
AURORA SCALISI ◽  
FRANCESCA CATALANO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm

scholarly journals Circadian Gating of Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Via Melatonin-Regulation of GSK3β

2012 ◽  
Vol 26 (11) ◽  
pp. 1808-1820 ◽  
Author(s):  
Lulu Mao ◽  
Robert T. Dauchy ◽  
David E. Blask ◽  
Lauren M. Slakey ◽  
Shulin Xiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Sleep Disturbances ◽  
Cancer Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Glycogen Synthase ◽  
Human Breast ◽  
Light At Night ◽  
Mesenchymal Transition ◽  
Age Related

Abstract Disturbed sleep-wake cycle and circadian rhythmicity are associated with cancer, but the underlying mechanisms are unknown. Employing a tissue-isolated human breast xenograft tumor nude rat model, we observed that glycogen synthase kinase 3β (GSK3β), an enzyme critical in metabolism and cell proliferation/survival, exhibits a circadian rhythm of phosphorylation in human breast tumors. Exposure to light-at-night suppresses the nocturnal pineal melatonin synthesis, disrupting the circadian rhythm of GSK3β phosphorylation. Melatonin activates GSK3β by inhibiting the serine-threonine kinase Akt phosphorylation, inducing β-catenin degradation and inhibiting epithelial-to-mesenchymal transition, a fundamental process underlying cancer metastasis. Thus, chronic circadian disruption by light-at-night via occupational exposure or age-related sleep disturbances may contribute to cancer incidence and the metastatic spread of breast cancer by inhibiting GSK3β activity and driving epithelial-to-mesenchymal transition in breast cancer patients.

Weak circadian rhythm increases neutropenia risk among breast cancer patients undergoing adjuvant chemotherapy

2017 ◽  
Vol 168 (2) ◽  
pp. 483-493 ◽  
Author(s):  
Wentao Li ◽  
Carol Chi-Hei Kwok ◽  
Dominic Chun-Wan Chan ◽  
Feng Wang ◽  
Lap Ah Tse
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Adjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Cancer Patients

scholarly journals The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer

PLoS Genetics ◽  
2016 ◽  
Vol 12 (9) ◽  
pp. e1006267 ◽  
Author(s):  
Ngoc-Han Ha ◽  
Jirong Long ◽  
Qiuyin Cai ◽  
Xiao Ou Shu ◽  
Kent W. Hunter
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Circadian Rhythm ◽  
Susceptibility Gene ◽  
Estrogen Receptor Negative

scholarly journals Genetic Variants in Circadian Rhythm Genes and Self-Reported Sleep Quality in Women with Breast Cancer

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Tricia D. LeVan ◽  
Peng Xiao ◽  
Gaurav Kumar ◽  
Kevin Kupzyk ◽  
Fang Qiu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Sleep Quality ◽  
Genetic Variants

scholarly journals Relationship between Night Shifts and Risk of Breast Cancer among Nurses: A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 680
Author(s):  
Javier Fagundo-Rivera ◽  
Juan Gómez-Salgado ◽  
Juan Jesús García-Iglesias ◽  
Carlos Gómez-Salgado ◽  
Selena Camacho-Martín ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Circadian Rhythm ◽  
Clock Genes ◽  
Early Adulthood ◽  
Reproductive Hormones ◽  
Night Time ◽  
Time Work ◽  
Nursing Professionals ◽  
Night Shifts

Background and objectives: The incidence of breast cancer worldwide has increased in recent decades, accounting for 1 in 3 neoplasms in women. Besides, nurses are mainly represented by the female collective, most of them, undertaking working conditions with intensive rotative and night shifts due to the 24-h pace of work of this profession. The objective of this study was to assess the possible relationship between shift work, especially night-time work, and the development of breast cancer among nurses. Materials and Methods: A systematic review of the literature was carried out through the consultation of the following databases: Cochrane Plus Library, PubMed, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, ScienceDirect, Scopus, and Dialnet. Records were selected between 2010 and 2020, in Spanish and English, which covered the association between breast cancer diagnosed among nursing professionals and rotating night shifts. Results: A total of 12 studies were identified after critical reading. Most of the studies found an association between breast cancer and consecutive rotating night shifts prolonged over time. Among the associated factors, the alteration of the circadian rhythm influenced the expression of peripheral clock genes, which was the same as reproductive hormones. The risk of breast cancer in nurses increased during early adulthood and after 5 or more years with 6 or more consecutive nights. Conclusions: The different studies of this review show significant associations between breast cancer and prolonged rotating night shifts. Similarly, there is a relationship between the alterations in certain circadian rhythm markers (such as melatonin), epigenetic markers (such as telomeres), and breast cancer that would require more studies in order to corroborate these findings.

Circulating tumoral cells lack circadian-rhythm in hospitalized metastasic breast cancer patients

2006 ◽  
Vol 8 (11) ◽  
pp. 826-829 ◽  
Author(s):  
José Ángel García-Sáenz ◽  
Miguel Martin ◽  
Marisa Maestro ◽  
Marta Vidaurreta ◽  
Silvia Veganzones ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Tumoral Cells

Temporal interrelationships among fatigue, circadian rhythm and depression in breast cancer patients undergoing chemotherapy treatment

2001 ◽  
Vol 10 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Joseph A. Roscoe ◽  
Gary R. Morrow ◽  
Jane T. Hickok ◽  
Peter Bushunow ◽  
Sara Matteson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Circadian Rhythm ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment
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