scholarly journals Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells

2011 ◽  
Vol 27 (4) ◽  
pp. 917-922 ◽  
Author(s):  
LIYONG HUANG ◽  
YE XU ◽  
GUOXIANG CAI ◽  
ZUQING GUAN ◽  
SANJUN CAI
Keyword(s):  
Colorectal Cancer ◽  
Rna Interference ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
S100a4 Expression ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

2015 ◽  
Vol 33 (4) ◽  
pp. 1579-1584 ◽  
Author(s):  
TETSUSHI YAMAMOTO ◽  
KENTARO UEMURA ◽  
KAHO MORIYAMA ◽  
KUNIKO MITAMURA ◽  
ATSUSHI TAGA
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Human Colorectal Cancer ◽  
Maple Syrup ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells

2017 ◽  
Vol 49 (10) ◽  
pp. 926-934 ◽  
Author(s):  
Nengquan Sheng ◽  
Li Yan ◽  
Weiqiang You ◽  
Gewen Tan ◽  
Jianfeng Gong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Upregulation of Polyamine Transport in Human Colorectal Cancer Cells

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 499 ◽  
Author(s):  
Misael Corral ◽  
Heather M. Wallace
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Colorectal Cancer ◽  
Polyamine Transport ◽  
Colorectal Cancer Cells ◽  
Polyamine Content ◽  
Human Colorectal Cancer Cells

Polyamines are essential growth factors that have a positive role in cancer cell growth. Their metabolic pathway and the diverse enzymes involved have been studied in depth in multiple organisms and cells. Polyamine transport also contributes to the intracellular polyamine content but this is less well-studied in mammalian cells. As the polyamine transporters could provide a means of selective drug delivery to cancer cells, a greater understanding of polyamine transport and its regulation is needed. In this study, transport of polyamines and polyamine content was measured and the effect of modulating each was determined in human colorectal cancer cells. The results provide evidence that upregulation of polyamine transport depends on polyamine depletion and on the rate of cell growth. Polyamine transport occurred in all colorectal cancer cell lines tested but to varying extents. The cell lines with the lowest basal uptake showed the greatest increase in response to polyamine depletion. Kinetic parameters for putrescine and spermidine suggest the existence of two separate transporters. Transport was shown to be a saturable but non-polarised process that can be regulated both positively and negatively. Using the polyamine transporter to deliver anticancer drugs more selectively is now a reality, and the ability to manipulate the polyamine transport process increases the possibility of using these transporters therapeutically.

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