scholarly journals A bone-seeking clone exhibits different biological properties from the ACHN parental human renal cell carcinoma in vivo and in vitro

2011 ◽  
Vol 27 (4) ◽  
pp. 1104-1110 ◽  
Author(s):  
JIANG WANG ◽  
ANMIN CHEN ◽  
CAIHONG YANG ◽  
HENG ZENG ◽  
JUN QI ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Biological Properties ◽  
Human Renal Cell Carcinoma

RNA-BINDING PROTEIN HUR BLOCKADE HAS POTENT ANTI-TUMOR ACTIVITIES IN HUMAN RENAL CELL CARCINOMA BOTH IN VITRO AND IN VIVO

2009 ◽  
Vol 181 (4S) ◽  
pp. 153-153 ◽  
Author(s):  
Sabrina Danilin ◽  
Lionel Thomas ◽  
Thomas Charles ◽  
Carole Sourbier ◽  
Véronique Lindner ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Human Renal Cell Carcinoma

Treatment of Human Renal Cell Carcinoma with High-Energy Shock Waves–A New in vivo/in vitro Model

1995 ◽  
Vol 55 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Wolfgang Roessler ◽  
Beate Rothgangel ◽  
Ferdinand Hofstaedter ◽  
Wolf F. Wieland
Keyword(s):  
Renal Cell Carcinoma ◽  
Shock Waves ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
In Vitro Model ◽  
High Energy ◽  
Human Renal Cell Carcinoma ◽  
Vitro Model

scholarly journals 379: Inhibition of the Nuclear Factor-Kappab Pathway has Potent Anti-Tumor Effect in Human Renal Cell Carcinoma in vitro and in vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 124-124
Author(s):  
Carole Sourbier ◽  
Jacques Steger ◽  
Véronique Lindner ◽  
Sabrina Danilin ◽  
Sylvie Rothhut ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Human Renal Cell Carcinoma

scholarly journals Effects of HMGA2 on the Epithelial-Mesenchymal Transition-Related Genes in ACHN Renal Cell Carcinoma Cells-Derived Xenografts in Nude Mice

2020 ◽  
Author(s):  
Guangyao Lv ◽  
Lingling Song ◽  
Guanyu Gong ◽  
Qian Chen ◽  
Kai Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nude Mice ◽  
Renal Cell ◽  
Epithelial Mesenchymal Transition ◽  
Human Renal Cell Carcinoma ◽  
Mesenchymal Transition

Abstract Background: The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2 in human renal cell carcinoma (RCC) is related with tumor invasiveness and poor prognosis. In the in vitro studies, HMGA2 knockdown was found to lead to decreased cell proliferation, decreased migration and changes in gene expression related with the epithelial-mesenchymal transition. Methods: In order to understand HMGA2’s effect in vivo , HMGA2 expression was knocked-down in ACHN cells using small hairpin RNA (shRNA). The HMGA2-deficient ACHN cells were xenografted into the BALB/c nude mice. The tumor growth was monitored and the expression of EMT-related genes was analyzed. Results: HMGA2 expression was confirmed to be knocked-down in the cultured and xenografted ACHN cells. The xenograft tumor of HMGA2-deficient cells demonstrated a retarded growth pattern compared with control. The expression of E-cadherin was increased, whereas N-cadherin and Snail were decreased in the HMGA2-deficient xenograft tumors. Conclusions: The present study suggested that the epigenetic regulation of EMT-related gene expression by HMGA2 exists both in the in vitro and in vivo conditions. It is likely that through this mechanism, HMGA2 regulates the cell growth in renal cell carcinoma.

Sign in / Sign up

Export Citation Format

Share Document