scholarly journals Comparison of the therapeutic efficacy of 188Rhenium-liposomes and liposomal doxorubicin in a 4T1 murine orthotopic breast cancer model

2011 ◽  
Author(s):  
Te-Wei Lee
Keyword(s):  
Breast Cancer ◽  
Therapeutic Efficacy ◽  
Liposomal Doxorubicin ◽  
Cancer Model ◽  
Breast Cancer Model

Therapeutic Efficacy of MUC1-Specific Cytotoxic T Lymphocytes and CD137 Co-Stimulation in a Spontaneous Breast Cancer Model

2004 ◽  
Vol 20 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Pinku Mukherjee ◽  
Teresa L. Tinder ◽  
Gargi D. Basu ◽  
Latha B. Pathangey ◽  
Lieping Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Therapeutic Efficacy ◽  
Cancer Model ◽  
Breast Cancer Model

Lifelong isoflavone exposure and its implications in an experimental breast cancer model

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
FJ Möller ◽  
K Wende ◽  
O Zierau ◽  
MC Bosland ◽  
MH Muders ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
Breast Cancer Model

Systemic Immunotherapy with Micellar Resiquimod–Polymer Conjugates Triggers a Robust Antitumor Response in a Breast Cancer Model

2021 ◽  
pp. 2100008
Author(s):  
Hamilton Kakwere ◽  
Hua Zhang ◽  
Elizabeth S. Ingham ◽  
Marina Nura‐Raie ◽  
Spencer K. Tumbale ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Model ◽  
Antitumor Response ◽  
Polymer Conjugates ◽  
Breast Cancer Model ◽  
Systemic Immunotherapy

scholarly journals Thermal analysis of laser irradiation-gold nanorod combinations at 808 nm, 940 nm, 975 nm and 1064 nm wavelengths in breast cancer model

2021 ◽  
Vol 38 (1) ◽  
pp. 1099-1110
Author(s):  
Leonardo Bianchi ◽  
Rachael Mooney ◽  
Yvonne R. Cornejo ◽  
Emiliano Schena ◽  
Jacob M. Berlin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Thermal Analysis ◽  
Laser Irradiation ◽  
Gold Nanorod ◽  
Cancer Model ◽  
Breast Cancer Model

scholarly journals Integrated transcription factor profiling with transcriptome analysis identifies L1PA2 transposons as global regulatory modulators in a breast cancer model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiayue-Clara Jiang ◽  
Joseph A. Rothnagel ◽  
Kyle R. Upton
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Disease Diagnosis ◽  
Integrated Analysis ◽  
Regulatory Sequences ◽  
Cancer Model ◽  
Mcf7 Cells ◽  
Epithelial Cancers ◽  
Breast Cancer Model

AbstractWhile transposons are generally silenced in somatic tissues, many transposons escape epigenetic repression in epithelial cancers, become transcriptionally active and contribute to the regulation of human gene expression. We have developed a bioinformatic pipeline for the integrated analysis of transcription factor binding and transcriptomic data to identify transposon-derived promoters that are activated in specific diseases and developmental states. We applied this pipeline to a breast cancer model, and found that the L1PA2 transposon subfamily contributes abundant regulatory sequences to co-ordinated transcriptional regulation in breast cancer. Transcription factor profiling demonstrates that over 27% of L1PA2 transposons harbour co-localised binding sites of functionally interacting, cancer-associated transcription factors in MCF7 cells, a cell line used to model breast cancer. Transcriptomic analysis reveals that L1PA2 transposons also contribute transcription start sites to up-regulated transcripts in MCF7 cells, including some transcripts with established oncogenic properties. In addition, we verified the utility of our pipeline on other transposon subfamilies, as well as on leukemia and lung carcinoma cell lines. We demonstrate that the normally quiescent regulatory activities of transposons can be activated and alter the cancer transcriptome. In particular, the L1PA2 subfamily contributes abundant regulatory sequences, and likely plays a global role in modulating breast cancer transcriptional regulation. Understanding the regulatory impact of L1PA2 on breast cancer genomes provides additional insights into cancer genome regulation, and may provide novel biomarkers for disease diagnosis, prognosis and therapy.

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