scholarly journals Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma

2011 ◽  
Vol 25 (4) ◽  
Author(s):  
Kataoka
Keyword(s):  
Gastric Carcinoma ◽  
Peritoneal Dissemination ◽  
Intraperitoneal Administration ◽  
Adenovirus Vector ◽  
Scirrhous Gastric Carcinoma

A novel K-samII/FGF-R2 autophosphorylation inhibitor is therapeutically useful for scirrhous gastric carcinoma with K-samII amplification

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 14070-14070
Author(s):  
M. Yashiro ◽  
K. Nakamura ◽  
T. Sawada ◽  
H. Kawajiri ◽  
T. Shimizu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Factor ◽  
Gastric Carcinoma ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Growth Factor Receptor ◽  
Carcinoma Cells ◽  
Apoptosis Pathway ◽  
Scirrhous Gastric Cancer ◽  
Scirrhous Gastric Carcinoma

14070 Background: Scirrhous gastric carcinoma, a diffusely infiltrating also known as linitis plastica-type carcinoma, carries the highest mortality of all gastric cancers. Scirrhous carcinoma cells with amplification of the activated K-samII gene, which encodes fibroblast growth factor receptor type 2 (FGF-R2), have a growth advantage during tumor progression The poor prognosis carried by scirrhous gastric cancer is closely associated with amplification of the K-samII/FGF-R2, a tyrosine kinase growth factor receptor. Ki23057, a newly developed small molecule acting K-samII/FGF-R2 inhibitor, is a kinase inhibitor that competes with ATP for the binding site in the kinase, thus strongly blocking phosphorylation of FGF-R2. The aim of the current study is to clarify the possibility of molecular target therapy with Ki23057 for treating scirrhous gastric cancer. Methods: Five human gastric cancer cell lines were used. OCUM-2MD3 and OCUM-8 were derived from scirrhous carcinomas. MKN-7, MKN-45 and MKN-74 cells were derived from non-scirrhous carcinomas. In vitro effects of Ki23057 on cell growth were determined by calculating the number of cancer cells. The influences of Ki23057 on the MAP kinase and PI3 kinase signaling pathways and the apoptosis pathway in the gastric cancer cells were also examined. For in vivo experiments, the Ki23057 was administered orally to mouse models of peritoneal dissemination. Results: K-samII amplification was found in OCUM-2MD3 and OCUM-8 cells, but not in MKN-7, MKN-45, or MKN-74 cells. Ki23057 significantly inhibited the proliferation of scirrhous cancer cells, but not non- scirrhous gastric carcinoma cells. Ki23057 decreased phosphorylation of K-samII/FGF-R2, ERK and Akt, and increased apoptosis in scirrhous cancer lines. The oral Ki23057 administration significantly (p<0.001) prolonged survival of mice with peritoneal dissemination following injection of OCUM-2MD3 scirrhous cancer cells. Conclusions: A novel K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, appears therapeutically promising in scirrhous gastric carcinoma with K-samII amplification. No significant financial relationships to disclose.

scholarly journals ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion

Oncogene ◽  
2010 ◽  
Vol 30 (12) ◽  
pp. 1413-1421 ◽  
Author(s):  
R Yagi ◽  
M Tanaka ◽  
K Sasaki ◽  
R Kamata ◽  
Y Nakanishi ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Gastric Carcinoma ◽  
Peritoneal Dissemination ◽  
Carcinoma Cells ◽  
Scirrhous Gastric Carcinoma ◽  
Adhesion And Invasion

scholarly journals ICAM-2 Gene Therapy for Peritoneal Dissemination of Scirrhous Gastric Carcinoma

2004 ◽  
Vol 10 (14) ◽  
pp. 4885-4892 ◽  
Author(s):  
Hiroaki Tanaka ◽  
Masakazu Yashiro ◽  
Takeshi Sunami ◽  
Yoji Sakate ◽  
Kinshi Kosaka ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Gastric Carcinoma ◽  
Peritoneal Dissemination ◽  
Scirrhous Gastric Carcinoma

scholarly journals A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma

Oncogene ◽  
2001 ◽  
Vol 20 (39) ◽  
pp. 5525-5532 ◽  
Author(s):  
Shinji Tanaka ◽  
Keishi Sugimachi ◽  
Hiroshi Saeki ◽  
Junko Kinoshita ◽  
Takefumi Ohga ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Novel Variant ◽  
Scirrhous Gastric Carcinoma ◽  
Type C ◽  
Von Willebrand

scholarly journals Surgical treatment of gastric carcinoma with peritoneal dissemination.

1987 ◽  
Vol 20 (5) ◽  
pp. 1022-1027 ◽  
Author(s):  
Yoshitaka YAMAMURA ◽  
Tsuyoshi KITO ◽  
Junichi SAKAMOTO ◽  
Kenzo YASUI ◽  
Takeshi MORIMOTO ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Gastric Carcinoma ◽  
Peritoneal Dissemination

A tumor-associated antigen in the scirrhous gastric carcinoma cell line MK-01 defined by monoclonal antibody S202

1989 ◽  
Vol 19 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Takashi Yokota ◽  
Takashi Masuko ◽  
Toshiharu Yamaguchi ◽  
Kazuya Kitamura ◽  
Toshio Takahashi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Gastric Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Gastric Carcinoma Cell ◽  
Gastric Carcinoma Cell Line ◽  
Tumor Associated Antigen ◽  
Scirrhous Gastric Carcinoma

scholarly journals Myofibroblasts are associated with the progression of scirrhous gastric carcinoma

2010 ◽  
Vol 1 (4) ◽  
pp. 547-551 ◽  
Author(s):  
YUHIKO FUYUHIRO ◽  
MASAKAZU YASHIRO ◽  
SATORU NODA ◽  
SHINICHIRO KASHIWAGI ◽  
JUNKO MATSUOKA ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Scirrhous Gastric Carcinoma
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