scholarly journals C4orf7 contributes to ovarian cancer metastasis by promoting cancer cell migration and invasion

2010 ◽  
Vol 24 (4) ◽  
Author(s):  
Ma
Keyword(s):  
Ovarian Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Cancer Metastasis ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

scholarly journals Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 813 ◽  
Author(s):  
Michelle K. Y. Siu ◽  
Yu-Xin Jiang ◽  
Jing-Jing Wang ◽  
Thomas H. Y. Leung ◽  
Chae Young Han ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Cancer Metastasis ◽  
Ovarian Cancer Cell ◽  
Lactate Production ◽  
Metabolic Reprogramming ◽  
Migration And Invasion ◽  
Hexokinase 2 ◽  
Cell Migration And Invasion

Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy. Hexokinase 2 (HK2) converts glucose to glucose-6-phosphate, the first committed step in glucose metabolism. Here, we demonstrated that HK2 was overexpressed in ovarian cancer and displayed significantly higher expression in ascites and metastatic foci. HK2 expression was significantly associated with advanced stage and high-grade cancers, and was an independent prognostic factor. Functionally, knockdown of HK2 in ovarian cancer cell lines and ascites-derived tumor cells hindered lactate production, cell migration and invasion, and cell stemness properties, along with reduced FAK/ERK1/2 activation and metastasis- and stemness-related genes. 2-DG, a glycolysis inhibitor, retarded cell migration and invasion and reduced stemness properties. Inversely, overexpression of HK2 promoted cell migration and invasion through the FAK/ERK1/2/MMP9 pathway, and enhanced stemness properties via the FAK/ERK1/2/NANOG/SOX9 cascade. HK2 abrogation impeded in vivo tumor growth and dissemination. Notably, ovarian cancer-associated fibroblast-derived IL-6 contributed to its up-regulation. In conclusion, HK2, which is regulated by the tumor microenvironment, controls lactate production and contributes to ovarian cancer metastasis and stemness regulation via FAK/ERK1/2 signaling pathway-mediated MMP9/NANOG/SOX9 expression. HK2 could be a potential prognostic marker and therapeutic target for ovarian cancer.

scholarly journals Epigenetic Targeting of Adipocytes Inhibits High-Grade Serous Ovarian Cancer Cell Migration and Invasion

2018 ◽  
Vol 16 (8) ◽  
pp. 1226-1240 ◽  
Author(s):  
Jessica Tang ◽  
Nicholas Pulliam ◽  
Ali Özeş ◽  
Aaron Buechlein ◽  
Ning Ding ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Migration ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Migration And Invasion ◽  
High Grade ◽  
Cancer Cell Migration ◽  
Serous Ovarian Cancer ◽  
Cell Migration And Invasion
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