scholarly journals Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA

2011 ◽  
Vol 25 (3) ◽  
Author(s):  
Ye
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Hepatocellular Carcinoma Cells

scholarly journals DNA Damage Induces Down-Regulation of Prp19 via Impairing Prp19 Stability in Hepatocellular Carcinoma Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e89976 ◽  
Author(s):  
Jie Yin ◽  
Yi-An Zhang ◽  
Tao-Tao Liu ◽  
Ji-Min Zhu ◽  
Xi-Zhong Shen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Hepatocellular Carcinoma Cells

Selective Down-Regulation of Glioma-Associated Oncogene 2 Inhibits the Proliferation of Hepatocellular Carcinoma Cells

2007 ◽  
Vol 67 (8) ◽  
pp. 3583-3593 ◽  
Author(s):  
Youngsoo Kim ◽  
Joon Won Yoon ◽  
Xiaokun Xiao ◽  
Nicholas M. Dean ◽  
Brett P. Monia ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Hepatocellular Carcinoma Cells

scholarly journals hsa_circ_0006916 promotes hepatocellular carcinoma progression by activating the miR-337-3p/STAT3 axis

2020 ◽  
Vol 25 (1) ◽  
Author(s):  
Xiao-Yong Zhou ◽  
Hui Yang ◽  
Yang-Qiu Bai ◽  
Xiu-Ling Li ◽  
Shuang-Yin Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Characteristics ◽  
Carcinoma Cells ◽  
Luciferase Reporter ◽  
Circular Rnas ◽  
Rt Pcr ◽  
Down Regulation ◽  
Hepatocellular Carcinoma Cells ◽  
And Function

Abstract Background Circular RNAs (circRNAs) are thought to be involved in the development of various malignancies. The expression and function of hsa_circ_0006916, a newly identified circRNA, in hepatocellular carcinoma remain unclear. Methods Quantitative RT-PCR was used to detect hsa_circ_0006916 in hepatocellular carcinoma. In vitro function assays were conducted to explore growth and invasion of hepatocellular carcinoma cells. Next, the mechanism of hsa_circ_0006916 function in hepatocellular carcinoma was determined by luciferase reporter and RIP assays. Results Hsa_circ_0006916 was substantially overexpressed in hepatocellular carcinoma tissues and cells. High levels of hsa_circ_0006916 in hepatocellular carcinoma patients were associated with advanced clinical characteristics. Down-regulation of hsa_circ_0006916 decreased the growth and invasion of hepatocellular carcinoma cells in vitro. The results suggested that hsa_circ_0006916 acted as a sponge of miR-337-3p and had an important functional use in the regulation of STAT3 levels in hepatocellular carcinoma cells. Moreover, miR-337-3p inhibition or STAT3 overexpression abolished the effect of hsa_circ_0006916 suppression on the progression of hepatocellular carcinoma cells. Conclusions Our data suggest a novel hsa_circ_0006916/miR-337-3p/STAT3 axis in hepatocellular carcinoma, and provide a new target for treatment.

scholarly journals Down-regulation of Phospho-Akt Is a Major Molecular Determinant of Bortezomib-Induced Apoptosis in Hepatocellular Carcinoma Cells

2008 ◽  
Vol 68 (16) ◽  
pp. 6698-6707 ◽  
Author(s):  
Kuen-Feng Chen ◽  
Pei-Yen Yeh ◽  
Kun-Huei Yeh ◽  
Yen-Shen Lu ◽  
Shang-Yi Huang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Hepatocellular Carcinoma Cells ◽  
Molecular Determinant ◽  
Induced Apoptosis
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