scholarly journals Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis

2007 ◽  
Author(s):  
Shahana Begum ◽  
Yan Zhang ◽  
Tomoaki Shintani ◽  
Shigeaki Toratani ◽  
J. Sato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Head And Neck ◽  
Fibroblast Growth Factor ◽  
Binding Protein ◽  
Angiogenic Factor ◽  
Fibroblast Growth ◽  
Heparin Binding ◽  
Immunohistochemical Expression ◽  
Factor Binding ◽  
Heparin Binding Protein

scholarly journals Heparin-Binding Protein 17/Fibroblast Growth Factor-Binding Protein-1 Knockout Inhibits Proliferation and Induces Differentiation of Squamous Cell Carcinoma Cells

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2684
Author(s):  
Tomoaki Shintani ◽  
Mirai Higaki ◽  
Tetsuji Okamoto
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Squamous Cell ◽  
Binding Protein ◽  
Squamous Cell Carcinomas ◽  
Fibroblast Growth ◽  
Heparin Binding ◽  
Heparin Binding Protein

Heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) has been observed to induce the tumorigenic potential of epithelial cells and is highly expressed in oral cancer cell lines and tissues. It is also recognized as a pro-angiogenic molecule because of its interaction with fibroblast growth factor (FGF)-2. In this study, we examined the functional role of HBp17/FGFBP-1 in A431 and HO-1-N-1 cells. Originally, HBp17/FGFBP-1 was purified from A431 cell-conditioned media based on its capacity to bind to FGF-1 and FGF-2. We isolated and established HBp17/FGFBP-1-knockout (KO)-A431 and KO-HO-1-N-1 cell lines using the clusters of regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) gene editing technology. The amount of FGF-2 secreted into conditioned medium decreased for A431-HBp17-KO and HO-1-N-1-HBp17-KO cells compared to their WT counterparts. Functional assessment showed that HBp17/FGFBP-1 KO inhibited cell proliferation, colony formation, and cell motility in vitro. It also inhibited tumor growth in vivo compared to controls, which confirmed the significant difference in growth in vitro between HBp17-KO cells and wild-type (WT) cells, indicating that HBp17/FGFBP-1 is a potent therapeutic target in squamous cell carcinomas (SCC) and oral squamous cell carcinomas (OSCC). In addition, complementary DNA/protein expression analysis followed by Gene Ontology and protein–protein interaction (PPI) analysis using the Database for Visualization and Integrated Discovery and Search Tool for the Retrieval of Interacting Genes/Proteins showed that both gene and protein expression related to epidermal development, cornification, and keratinization were upregulated in A431-HBp17-KO and HO-1-N-1-KO cells. This is the first discovery of a novel role of HBp17/FGFBP-1 that regulates SCC and OSCC cell differentiation.

scholarly journals Expression of Fibroblast Growth Factor Binding Protein in Head and Neck Cancer

2009 ◽  
Vol 135 (9) ◽  
pp. 896 ◽  
Author(s):  
Weimin Li ◽  
Chuan Wang ◽  
Steven K. Juhn ◽  
Frank G. Ondrey ◽  
Jizhen Lin
Keyword(s):  
Head And Neck Cancer ◽  
Growth Factor ◽  
Head And Neck ◽  
Fibroblast Growth Factor ◽  
Neck Cancer ◽  
Binding Protein ◽  
Fibroblast Growth ◽  
Factor Binding

scholarly journals Mitogen-induced expression of the fibroblast growth factor-binding protein is transcriptionally repressed through a non-canonical E-box element.

2000 ◽  
Vol 275 (50) ◽  
pp. 39801
Author(s):  
Violaine K. Harris ◽  
Christine M. Coticchia ◽  
Heinz-Joachim List ◽  
Anton Wellstein ◽  
Anna Tate Riegel
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Binding Protein ◽  
Fibroblast Growth ◽  
Induced Expression ◽  
Factor Binding ◽  
E Box

scholarly journals Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Elena Tassi ◽  
Khalid A. Garman ◽  
Marcel O. Schmidt ◽  
Xiaoting Ma ◽  
Khaled W. Kabbara ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Binding Protein ◽  
Fibroblast Growth ◽  
Factor Binding ◽  
Carbohydrate And Lipid Metabolism

A fibroblast growth factor binding protein in human cerebral spinal fluid

Neuroreport ◽  
1995 ◽  
Vol 6 (6) ◽  
pp. 886-888 ◽  
Author(s):  
Anne Hanneken ◽  
Sally Frautschy ◽  
Douglas Galasko ◽  
Andrew Baird
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cerebral Spinal Fluid ◽  
Binding Protein ◽  
Spinal Fluid ◽  
Fibroblast Growth ◽  
Factor Binding
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