scholarly journals Aging of patients with hepatitis C virus-associated hepatocellular carcinoma: Long-term trends in Japan

2006 ◽  
Author(s):  
Naota Taura ◽  
Keisuke Hamasaki ◽  
Kazuhiko Nakao ◽  
Tatsuki Ichikawa ◽  
Daisuke Nishimura ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Long Term Trends

Increasing hepatitis C virus-associated hepatocellular carcinoma mortality and aging: Long term trends in Japan

2006 ◽  
Vol 34 (2) ◽  
pp. 130-134 ◽  
Author(s):  
N TAURA ◽  
H YATSUHASHI ◽  
K HAMASAKI ◽  
K NAKAO ◽  
M DAIKOKU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Long Term Trends

scholarly journals Long-Term Prognostic Factors after Hepatic Resection for Hepatitis C Virus-Related Hepatocellular Carcinoma, with a Special Reference to Viral Status

Liver Cancer ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 261-276 ◽  
Author(s):  
Masaki Koda ◽  
Shogo Tanaka ◽  
Shigekazu Takemura ◽  
Hiroji Shinkawa ◽  
Masahiko Kinoshita ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatic Resection ◽  
Special Reference

Improvement of Long-Term Outcomes in Hepatitis C Virus Antibody–Positive Patients with Hepatocellular Carcinoma after Hepatectomy in the Modern Era

2011 ◽  
Vol 35 (5) ◽  
pp. 1072-1084 ◽  
Author(s):  
Ken Shirabe ◽  
Kazuki Takeishi ◽  
Akinobu Taketomi ◽  
Hideaki Uchiyama ◽  
Hiroto Kayashima ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Antibody ◽  
Long Term Outcomes ◽  
Hepatitis C Virus Antibody ◽  
Modern Era

scholarly journals Mortality rates and risk factors in 1412 Japanese patients with decompensated hepatitis C virus-related cirrhosis: a retrospective long-term cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shunichiro Fujiyama ◽  
Norio Akuta ◽  
Hitomi Sezaki ◽  
Mariko Kobayashi ◽  
Yusuke Kawamura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Survival Rates ◽  
Japanese Patients ◽  
Independent Risk Factors

Abstract Background Hepatitis C virus is the leading cause of liver cirrhosis and hepatocellular carcinoma in Japan. We aimed to examine the long-term (> 20 years) mortality and hepatocellular carcinoma rates and associated risk factors in 1412 Japanese patients with decompensated hepatitis C virus-related cirrhosis (Child–Pugh B or C). Methods Cumulative survival and hepatocellular carcinoma rates were determined using Kaplan–Meier analysis. Independent risk factors were identified by multivariate analysis. A two-tailed P-value of < 0.05 was considered significant. Results The patients were followed up for a median of 2 years (range 0.5–24.2 years). In total, 62.3%, 41.7%, 4.7%, and 68.3% of the patients had a history of hepatocellular carcinoma, ascites, hepatic encephalopathy, and esophageal varices, respectively. The 1-, 5-, 10-, and 20-year cumulative overall survival rates in the total cohort was 74.9%, 29.0%, 9.1%, and 1.4%, respectively. The 1-, 3-, 5-, and 10-year cumulative survival rates for patients without hepatocellular carcinoma were 93.1%, 54.4%, 18.2%, and 4.0%, respectively, and the corresponding cumulative post-decompensation hepatocellular carcinoma rates were 14.0%, 31.6%, 46.1%, and 66.2%, respectively. The independent risk factors for mortality were older age, Child–Pugh C cirrhosis, the presence of hepatocellular carcinoma, low estimated glomerular filtration rate, low serum sodium level, low platelet count, and high γ-glutamyl transferase and α-fetoprotein levels for all patients and older age, Child–Pugh C cirrhosis, and low estimated glomerular filtration rate for patients without hepatocellular carcinoma. Overall, 1035 patients (73.3%) died; the causes of death were liver failure with/without hepatocellular carcinoma, pneumonia, sepsis, cardiovascular disease, and non-hepatocellular carcinoma malignancies. The corresponding morality rates per person-year were 133.4, 59.9, 10.9, 10.6, 9.0, and 5.2, respectively. Conclusions Among Japanese patients with decompensated hepatitis C virus-related cirrhosis, hepatocellular carcinoma is associated with poor prognosis. Our results highlight the importance of managing liver-related events, including hepatocellular carcinoma, in these patients.

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