Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis

2005 ◽  
Author(s):  
Mitsuo Goto ◽  
Tetsuya Tsukamoto ◽  
Ken-ichi Inada ◽  
Tsutomu Mizoshita ◽  
Tetsuya Ogawa ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue

Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas

2008 ◽  
Vol 134 (12) ◽  
pp. 1267-1276 ◽  
Author(s):  
Davut Pehlivan ◽  
Esra Gunduz ◽  
Mehmet Gunduz ◽  
Hitoshi Nagatsuka ◽  
Levent Bekir Beder ◽  
...  
Keyword(s):  
Head And Neck ◽  
Loss Of Heterozygosity ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Cell Carcinomas ◽  
Chromosome 14Q

scholarly journals Differential mechanisms ofCDKN2A(p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

2014 ◽  
Vol 135 (4) ◽  
pp. 887-895 ◽  
Author(s):  
Annette M. Lim ◽  
Hongdo Do ◽  
Richard J. Young ◽  
Stephen Q. Wong ◽  
Christopher Angel ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue

Gene of the month: Cornulin

2021 ◽  
pp. jclinpath-2021-208011
Author(s):  
Rajandeep Kaur ◽  
Anshika Chauhan ◽  
Shabir Ahmad Bhat ◽  
Debajyoti Chatterjee ◽  
Sushmita Ghoshal ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Amino Acid ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Squamous Cell Carcinomas ◽  
Oesophageal Squamous Cell Carcinoma ◽  
Squamous Cells ◽  
The Poor ◽  
Differentiation Marker

Cornulin (CRNN) gene encodes a 495 amino acid long protein and is located on chromosome 1q21.3. Primarily, it functions as the marker of differentiation. Initially, it was found to be specific for the squamous cells of oesophagus. However, later on, several studies have revealed the presence of Cornulin downregulation in various epithelial squamous cell carcinomas of the head and neck, oesophagus and cervix and clinically associated it with worsening of cancer and the poor prognosis. Cornulin levels also showed dysregulation in other diseases such as Eczema and Psoriasis. Besides the differentiation marker, it was identified to be involved in the stress response. The studies, in psoriasis and oesophageal squamous cell carcinoma, has elucidated that the dysregulation in the Cornulin is associated with the cell cycle events such as G1/S transition. However, the actual function of Cornulin is still yet to be explored in detail.

Prognostic value of biomarkers in tissue microarrays (TMAs) of squamous cell carcinomas of the oral tongue (SCCOT).

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 5548-5548
Author(s):  
W. N. William ◽  
M. Nunez ◽  
X. Gu ◽  
R. W. Jacobs ◽  
A. M. Litvak ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Value ◽  
Tissue Microarrays ◽  
Squamous Cell Carcinomas ◽  
Oral Tongue

Clinical significance of lymphatic and blood vessel invasion in oral tongue squamous cell carcinomas

Oral Oncology ◽  
2012 ◽  
Vol 48 (4) ◽  
pp. 320-324 ◽  
Author(s):  
Chieko Michikawa ◽  
Narikazu Uzawa ◽  
Kou Kayamori ◽  
Itaru Sonoda ◽  
Yoshio Ohyama ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Clinical Significance ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Blood Vessel Invasion ◽  
Oral Tongue ◽  
Vessel Invasion
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