The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: Time- and p53 expression-dependency of anti-cancer drugs

2005 ◽  
Author(s):  
Nobuhisa Matsuhashi ◽  
Masanao Saio ◽  
Atsushi Matsuo ◽  
Yasuyuki Sugiyama ◽  
Shigetoyo Saji
Keyword(s):  
Gastric Cancer ◽  
Cancer Drugs ◽  
P53 Expression ◽  
Anti Cancer ◽  
Induction Of Apoptosis

Mapping Binding Sites of Potential Anti-Cancer Drugs on Tubulin

2000 ◽  
Vol 6 (S2) ◽  
pp. 236-237
Author(s):  
Huilin Li ◽  
Eva Nogales ◽  
Kenneth H. Downing
Keyword(s):  
Cell Cycle ◽  
Side Effects ◽  
Binding Sites ◽  
Microtubule Dynamics ◽  
Cancer Drugs ◽  
Substantial Fraction ◽  
Dynamic Activity ◽  
Anti Cancer ◽  
Main Protein ◽  
Induction Of Apoptosis

Microtubules are involved in many activities within the cell that require highly dynamic activity. For examples, microtubules can grow and shrink as they explore the cell, and the entire microtubule cytoskeleton is restructured as cells prepare for division. Interfering with microtubule dynamics can have serious consequences for the health of the cell, especially in cells that are rapidly dividing. The result of disrupting the normal dynamics is generally an interruption of the cell cycle and consequent induction of apoptosis. This behavior has been exploited with a number of anti-cancer drugs that target tubulin, the main protein in microtubules. Drugs are currently in use that either stabilize or destabilize microtubules. Among the most widely used is Taxol, one of the microtubule stabilizing drugs. Because Taxol produces a range of serious side effects and a substantial fraction of patients treated with Taxol eventually develop resistance to the drug, there is an active search for other drugs that might be more selective and less prone to resistance.

Study on Biomaterials of Anti-Gastric Trametenolic Acid B Semi-Synthetic Derivatives

2014 ◽  
Vol 918 ◽  
pp. 32-35
Author(s):  
Xi Ming Yan ◽  
Ming Ruo Ding ◽  
Ming Guo Liu ◽  
Jun Zhi Wang ◽  
Nian Yu Huang
Keyword(s):  
Gastric Cancer ◽  
Hot Spots ◽  
Medicinal Chemistry ◽  
Cancer Drugs ◽  
Physiological Conditions ◽  
Anti Cancer ◽  
Bioactive Ingredients ◽  
Ph Decrease ◽  
Synthetic Derivatives

Discovery of bioactive ingredients from plants and fungi is always the hot spots in medicinal chemistry. The trametenolic acid B was a bioactive lanostane-type triterpenoid inTrametes lactinea(Berk.) Pat. In this work, four semi-synthetic derivatives were synthesized, characterized and evaluated the anti-gastric cancer activities against HGC-27 cells with the aim of obtaining better anti-tumor agents. The compounds2aand3bpossessed good anti-proliferative effects under normal physiological conditions, and their anti-cancer effects increased as the pH decrease to 5.5 with the IC50of 17.55 and 10.63 μM, respectively. These compounds might be further developed as anti-gastric cancer drugs.

scholarly journals Identification of Candidate Genes Determining Chemosensitivity to Anti-cancer Drugs of Gastric Cancer Cell Lines

2009 ◽  
Vol 32 (11) ◽  
pp. 1936-1939 ◽  
Author(s):  
Tomoki Nakamura ◽  
Noriyuki Nakatsu ◽  
Yoko Yoshida ◽  
Kanami Yamazaki ◽  
Shingo Dan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Candidate Genes ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Gastric Cancer Cell Lines

Prognostic effects of oral anti-cancer drugs as adjuvant chemotherapy for 2 years after gastric cancer surgery

Surgery Today ◽  
2012 ◽  
Vol 42 (8) ◽  
pp. 734-740 ◽  
Author(s):  
Toshiro Okuyama ◽  
Daisuke Korenaga ◽  
Ai Edagawa ◽  
Shinji Itoh ◽  
Eiji Oki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Chemotherapy ◽  
Cancer Surgery ◽  
Cancer Drugs ◽  
Gastric Cancer Surgery ◽  
Anti Cancer

scholarly journals Cancer/Testis Antigen CAGE Exerts Negative Regulation on p53 Expression through HDAC2 and Confers Resistance to Anti-cancer Drugs

2010 ◽  
Vol 285 (34) ◽  
pp. 25957-25968 ◽  
Author(s):  
Youngmi Kim ◽  
Hyunmi Park ◽  
Deokbum Park ◽  
Yun-Sil Lee ◽  
Jongseon Choe ◽  
...  
Keyword(s):  
Negative Regulation ◽  
Cancer Testis Antigen ◽  
Cancer Drugs ◽  
P53 Expression ◽  
Anti Cancer ◽  
Cancer Testis

scholarly journals Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Zhenhua Guan ◽  
Jing Chen ◽  
Xueliang Li ◽  
Na Dong
Keyword(s):  
Gastric Cancer ◽  
Lipid Peroxidation ◽  
Cancer Cells ◽  
Salvia Miltiorrhiza ◽  
Chinese Herb ◽  
Tanshinone Iia ◽  
Gastric Cancer Cells ◽  
P53 Expression ◽  
Anti Cancer ◽  
Pharmacologically Active

Abstract Gastric cancer represents a malignant type of cancer worldwide. Tanshinone IIA (Tan IIA), a pharmacologically active component isolated from the rhizome of the Chinese herb Salvia miltiorrhiza Bunge (Danshen), has been reported to possess an anti-cancer effect in gastric cancer. However, its mechanisms are still not fully understood. In the present study, we found that Tan IIA induced ferroptosis in BGC-823 and NCI-H87 gastric cancer cells. Tan IIA increased lipid peroxidation and up-regulated Ptgs2 and Chac1 expression, two markers of ferroptosis. Ferrostatin-1 (Fer-1), an inhibitor of lipid peroxidation, inhibited Tan IIA caused-lipid peroxidation and Ptgs2 and Chac1 expression. In addition, Tan IIA also up-regulated p53 expression and down-regulated xCT expression. Tan IIA caused decreased intracellular glutathione (GSH) level and cysteine level and increased intracellular reactive oxygen species (ROS) level. p53 knockdown attenuated Tan IIA-induced lipid peroxidation and ferroptosis. Tan IIA also induced lipid peroxidation and ferroptosis in BGC-823 xenograft model, and the anti-cancer effect of Tan IIA was attenuated by Fer-1 in vivo. Therefore, Tan IIA could suppress the proliferation of gastric cancer via inducing p53 upregulation-mediated ferroptosis. Our study have identified a novel mechanism of Tan IIA against gastric cancer, and might provide a critical insight into the application of Tan IIA in gastric cancer intervention.

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