Estrogen receptor α and β, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breast

2004 ◽  
Author(s):  
Achim Rody ◽  
Raihanatou Diallo ◽  
Christopher Poremba ◽  
Regina Speich ◽  
Pia Wuelfing ◽  
...  
2016 ◽  
Vol 40 (8) ◽  
pp. 1090-1099 ◽  
Author(s):  
Christopher J. VandenBussche ◽  
Ashley Cimino-Mathews ◽  
Ben Ho Park ◽  
Leisha A. Emens ◽  
Theodore N. Tsangaris ◽  
...  

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e18524-e18524
Author(s):  
Lilit Karapetyan ◽  
Jailan Elayoubi ◽  
Seda Grigoryan ◽  
Gennady Kuzin ◽  
Deimante Tamkus

2019 ◽  
Vol 28 (2) ◽  
pp. 210-215 ◽  
Author(s):  
Samantha A. Moore ◽  
Hollis M. Notgrass ◽  
Travis W. Vandergriff ◽  
Sunati Sahoo

Mammary Paget’s disease is rare and comprises about 0.62% of all breast cancer cases, only 1.65% of which occur in male patients. This case report involves a 76-year-old man who presented to his primary care physician with an itching, scaly, unilateral lesion involving the nipple skin. He underwent wide local excision of the lesion for a diagnosis of Bowen’s disease (squamous cell carcinoma in situ). Histologic examination of the specimen revealed mammary Paget’s disease with ductal carcinoma in situ in the underlying breast tissue. A panel of immunohistochemical stains revealed the Paget cells to be positive for cytokeratin 7, MUC1, GATA3, and androgen receptor and negative for cytokeratins 5/6, p63, SOX10, and MART-1/Melan-A. Paget cells were also negative for estrogen receptor and progesterone receptor, and positive for HER2/neu. However, the underlying ductal carcinoma in situ was positive for both estrogen receptor and progesterone receptor and negative for HER2/neu. This discordance, supported by the current literature, suggests an alternative etiology for Paget’s disease in certain cases that cannot be explained by the well-established epidermotropic and transformative theories of Paget’s disease evolution.


The Breast ◽  
2011 ◽  
Vol 20 (6) ◽  
pp. 529-533 ◽  
Author(s):  
Anna F. Meyerson ◽  
Juan N. Lessing ◽  
Kaoru Itakura ◽  
Nola M. Hylton ◽  
Dulcy E. Wolverton ◽  
...  

2007 ◽  
Vol 68 (1) ◽  
pp. 235 ◽  
Author(s):  
Kadri Altundag ◽  
Mehmet E Tezcan ◽  
Mehmet Ozen ◽  
Fatih Karaahmet ◽  
Nilufer Bulut

Cancer ◽  
2006 ◽  
Vol 106 (10) ◽  
pp. 2113-2118 ◽  
Author(s):  
R. Barry Hird ◽  
Alfred Chang ◽  
Vincent Cimmino ◽  
Kathleen Diehl ◽  
Michael Sabel ◽  
...  

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