scholarly journals PRMT1 expression predicts sensitivity to platinum‑based chemotherapy in patients with ovarian serous carcinoma

2020 ◽  
Vol 21 (2) ◽  
Author(s):  
Hiroaki Matsubara ◽  
Takeshi Fukuda ◽  
Yuichiro Awazu ◽  
Shigenori Nanno ◽  
Masahiro Shimomura ◽  
...  
Keyword(s):  
Serous Carcinoma ◽  
Ovarian Serous Carcinoma ◽  
Platinum Based Chemotherapy

scholarly journals Expression of UCP2 is associated with sensitivity to platinum‑based chemotherapy for ovarian serous carcinoma

2018 ◽  
Author(s):  
Masaru Kawanishi ◽  
Takeshi Fukuda ◽  
Masahiro Shimomura ◽  
Yuta Inoue ◽  
Takuma Wada ◽  
...  
Keyword(s):  
Serous Carcinoma ◽  
Ovarian Serous Carcinoma ◽  
Platinum Based Chemotherapy

β-catenin nuclear localization is associated with grade in ovarian serous carcinoma

2003 ◽  
Vol 88 (3) ◽  
pp. 363-368 ◽  
Author(s):  
Christine M Lee ◽  
Hyun Shvartsman ◽  
Michael T Deavers ◽  
Shao-Chun Wang ◽  
Weiya Xia ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Serous Carcinoma ◽  
Ovarian Serous Carcinoma

scholarly journals Gene Set-Based Functionome Analysis of Pathogenesis in Epithelial Ovarian Serous Carcinoma and the Molecular Features in Different FIGO Stages

2016 ◽  
Vol 17 (6) ◽  
pp. 886 ◽  
Author(s):  
Chia-Ming Chang ◽  
Chi-Mu Chuang ◽  
Mong-Lien Wang ◽  
Ming-Jie Yang ◽  
Cheng-Chang Chang ◽  
...  
Keyword(s):  
Serous Carcinoma ◽  
Ovarian Serous Carcinoma ◽  
Gene Set ◽  
Molecular Features

Treatment of uterine papillary serous carcinoma with platinum-based chemotherapy and paclitaxel

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 267-272 ◽  
Author(s):  
A. P. Vaidya ◽  
R. Littell ◽  
C. Krasner ◽  
L. R. Duska
Keyword(s):  
Endometrial Cancer ◽  
Gynecologic Oncology ◽  
High Response Rate ◽  
Serous Carcinoma ◽  
Gynecologic Oncology Group ◽  
First Line ◽  
Uterine Papillary Serous Carcinoma ◽  
Platinum Based Chemotherapy ◽  
Papillary Serous Carcinoma ◽  
Line Chemotherapy

Uterine papillary serous carcinoma (UPSC) is more aggressive than endometrioid endometrial cancer, as it often presents with advanced disease and follows a pattern of spread that resemblesthe serous carcinoma of the ovary. There exists little data on evaluating the combination of carboplatin and paclitaxel in UPSC. Institutional Review Board permission was obtained for a retrospective review. Tumor registry search was used to identify all patients with UPSC from 1990 to 2003. Charts were retrospectively evaluated from patients who had received at least three cycles of carboplatin and paclitaxel as first-line chemotherapy. Only patients with histologically confirmed UPSC who were treated first line with carboplatin/paclitaxel chemotherapy were included. Nineteen patients with UPSC were identified, who were treated with carboplatin and paclitaxel in the first-line adjuvant setting after initial surgical cytoreduction. All patients received at least three cycles, with 12 of the 19 patients receiving six cycles. Five patients were treated with consolidation radiotherapy following first-line chemotherapy. Mean age was 69 years (range 55–88). The majority of patients had stage III disease (n= 11). Mean follow-up for the group was 29.5 months (7–76 months). A median progression-free interval of 12 months was seen across the entire cohort. Fourteen patients achieved a complete response following chemotherapy. The results of Gynecologic Oncology Group protocol 122 suggest that patients with advanced endometrial cancer have an improved progression-free survival when treated primarily with chemotherapy rather than radiation therapy. The results of our study show a high response rate to paclitaxel/carboplatin outpatient chemotherapy in a group of patients historically believed to have chemoresistant disease. Further prospective study of this regimen is planned.

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