scholarly journals Chloroquine increases the anti‑cancer activity of epirubicin in A549 lung cancer cells

2020 ◽  
Author(s):  
Ai‑Ling Liang ◽  
Jing Zhang ◽  
Shen‑Lin Du ◽  
Bin Zhang ◽  
Xuan Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

scholarly journals Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides

MedChemComm ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 116-119 ◽  
Author(s):  
Fabrizio Olivito ◽  
Nicola Amodio ◽  
Maria Luisa Di Gioia ◽  
Monica Nardi ◽  
Manuela Oliverio ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Preliminary Evaluation ◽  
Natural Analogue ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

In this work we synthesized and tested a series of unsaturated disulfides. Two compounds showed a promising anticancer activity in vitro on A549 lung cancer cells compared to the natural analogue.

scholarly journals Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

2020 ◽  
Vol 27 (11) ◽  
pp. 3018-3024 ◽  
Author(s):  
Shan Tian ◽  
Kandasamy Saravanan ◽  
Ramzi A. Mothana ◽  
Govindan Ramachandran ◽  
Govindan Rajivgandhi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Avicennia Marina ◽  
Lung Cancer Cells ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

scholarly journals Erratum: Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Seong-Hoon Kim ◽  
Hye Guk Ryu ◽  
Juhyun Lee ◽  
Joon Shin ◽  
Amaravadhi Harikishore ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Lung Cancer Cells ◽  
Damage Repair ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Potent anti-cancer activity of Alnus nitida against lung cancer cells; in vitro and in vivo studies

2019 ◽  
Vol 110 ◽  
pp. 254-264 ◽  
Author(s):  
Moniba Sajid ◽  
Chao Yan ◽  
Dawei Li ◽  
Siva Bharath Merugu ◽  
Hema Negi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
In Vivo Studies ◽  
Anti Cancer ◽  
Cancer Activity

Volatile Inhibitors of Phosphatidylinositol-3-Kinase (PI3K) Pathway: Anticancer Potential of Aroma Compounds of Plant Essential Oils

2018 ◽  
Vol 18 (1) ◽  
pp. 87-109 ◽  
Author(s):  
Manobjyoti Bordoloi ◽  
Surovi Saikia ◽  
Bhaskor Kolita ◽  
Rajeev Sarmah ◽  
Sonali Roy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Essential Oil ◽  
Essential Oils ◽  
Cancer Cells ◽  
Pi3k Pathway ◽  
Lung Cancer Cells ◽  
Phosphatidylinositol 3 Kinase ◽  
Anti Cancer ◽  
A549 Lung ◽  
Phosphatidylinositol 3

Background: Cancer is a grave health problem for the world as the global cancer burden rises to 14 million new cases with 8.2 million deaths every year which is expected to rise by 70% in the next 2 decades as reported by the WHO.These steady rises in death demand for rapid developments in anti-cancer agents. Essential oils, being natural and multi-component complex systems have recently attracted a lot of attention in this search for novel anti-cancer agents. Materials and Methods: The pharmaceutical attributes of essential oil components, specifically focusing on their affinity towards COX, 5-LOX, AKT, MDM2, PDK1 and mTOR which defines the phosphatidylinositol-3- kinase (PI3K) pathway, were assessed. 123 compounds present in essential oils of different plants were analyzed for their drug like attributes which were then allowed to dock with PI3K dependent receptors crucial for the development of cancer malignancies. Among them, 21 compounds were filtered possessing high druglikeness with favourable metabolism offered by major cytochromeP450 isoforms. Finally, the best docked compounds with highest binding affinities were employed for building a ligand based pharmacophore. Being inhibitors of P-glycoproteins, these molecules also exhibited good absorption profiles and noncarcinogenic properties. Further from these 21, six compounds were evaluated against A549 lung cancer cells. Results: The pharmacophoric feature obtained can be applied for both designing and screening moieties for active inhibitors of the phosphatidylinositol-3-kinase pathway specifically from essential oil compounds and these final 21 compounds can be further promoted to studies for anti-cancer drug development. Among these, six compounds exhibited promising inhibitory results against A549 lung cancer cells. Furthermore, immunoblotting assay confirmed the efficacy of the compounds for inhibiting mTOR and AKT enzymes which are bandmasters for downstream signaling of thePI3K pathway. Conclusion: Methyl nonanoate, (R)-citronellol, cis-carveol (L-carveol), 3-methyl-Cyclohexanone, 4-carene and thujopsene were finally screened for PI3K targeted anti-cancer therapies which may find direct application as inhalers or sprays against lung cancer as these compounds are highly volatile.

scholarly journals Anti-cancer effects of 3,5-dimethylaminophenol in A549 lung cancer cells

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205249 ◽  
Author(s):  
Pei-Ying Lin ◽  
Yu-Jung Chang ◽  
Yu-Chen Chen ◽  
Chin-Hung Lin ◽  
Pinar Erkekoglu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Anti Cancer ◽  
A549 Lung

Enhanced anti-cancer activity of chitosan loaded Morinda citrifolia essential oil against A549 human lung cancer cells

2020 ◽  
Vol 164 ◽  
pp. 4010-4021
Author(s):  
Govindan Rajivgandhi ◽  
Kandasamy Saravanan ◽  
Govindan Ramachandran ◽  
Jia-Ling Li ◽  
Lingzi Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Essential Oil ◽  
Cancer Cells ◽  
Human Lung ◽  
Morinda Citrifolia ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Anti Cancer ◽  
Human Lung Cancer Cells ◽  
Cancer Activity

scholarly journals 18β-Glycyrrhetinic Acid Has Anti-Cancer Effects via Inducing Apoptosis and G2/M Cell Cycle Arrest, and Inhibiting Migration of A549 Lung Cancer Cells

2021 ◽  
Vol Volume 14 ◽  
pp. 5131-5144
Author(s):  
Ying-Hua Luo ◽  
Cheng Wang ◽  
Wan-Ting Xu ◽  
Yu Zhang ◽  
Tong Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Glycyrrhetinic Acid ◽  
Lung Cancer Cells ◽  
M Cell ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
A549 Lung
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