scholarly journals AMPK decreases ERK1/2 activity and cancer cell sensitivity to nutrition deprivation by mediating a positive feedback loop involving eEF2K

2020 ◽  
Author(s):  
Shujuan Tong ◽  
Tao Zhou ◽  
Yufen Meng ◽  
Dongqin Xu ◽  
Jianping Chen
Keyword(s):  
Cancer Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop ◽  
Cell Sensitivity ◽  
Nutrition Deprivation

scholarly journals The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers

Oncogene ◽  
2021 ◽  
Author(s):  
Hirokazu Kimura ◽  
Ryota Sada ◽  
Naoki Takada ◽  
Akikazu Harada ◽  
Yuichiro Doki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wnt Signaling ◽  
Cancer Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Ductal Adenocarcinoma ◽  
Cancer Cell Proliferation ◽  
Positive Feedback Loop ◽  
Dkk1 Expression ◽  
Foxm1 Expression

AbstractDickkopf1 (DKK1) is overexpressed in various cancers and promotes cancer cell proliferation by binding to cytoskeleton-associated protein 4 (CKAP4). However, the mechanisms underlying DKK1 expression are poorly understood. RNA sequence analysis revealed that expression of the transcription factor forkhead box M1 (FOXM1) and its target genes concordantly fluctuated with expression of DKK1 in pancreatic ductal adenocarcinoma (PDAC) cells. DKK1 knockdown decreased FOXM1 expression and vice versa in PDAC and esophageal squamous cell carcinoma (ESCC) cells. Inhibition of either the DKK1-CKAP4-AKT pathway or the ERK pathway suppressed FOXM1 expression, and simultaneous inhibition of both pathways showed synergistic effects. A FOXM1 binding site was identified in the 5ʹ-untranslated region of the DKK1 gene, and its depletion decreased DKK1 expression and cancer cell proliferation. Clinicopathological and database analysis revealed that PDAC and ESCC patients who simultaneously express DKK1 and FOXM1 have a poorer prognosis. Multivariate analysis demonstrated that expression of both DKK1 and FOXM1 is the independent prognostic factor in ESCC patients. Although it has been reported that FOXM1 enhances Wnt signaling, FOXM1 induced DKK1 expression independently of Wnt signaling in PDAC and ESCC cells. These results suggest that DKK1 and FOXM1 create a positive feedback loop to promote cancer cell proliferation.

scholarly journals IKKβ Enforces a LIN28B/TCF7L2 Positive Feedback Loop That Promotes Cancer Cell Stemness and Metastasis

2015 ◽  
Vol 75 (8) ◽  
pp. 1725-1735 ◽  
Author(s):  
Chong Chen ◽  
Fengqi Cao ◽  
Lipeng Bai ◽  
Yan Liu ◽  
Junling Xie ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop

scholarly journals ALYREF Drives Cancer Cell Proliferation Through an ALYREF-MYC Positive Feedback Loop in Glioblastoma

2021 ◽  
Vol Volume 14 ◽  
pp. 145-155
Author(s):  
Jianjun Wang ◽  
Yuchen Li ◽  
Binbin Xu ◽  
Jiao Dong ◽  
Haiyan Zhao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Cancer Cell Proliferation ◽  
Positive Feedback Loop
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