scholarly journals Expression pattern of p‑Smad2/Smad4 as a predictor of survival in invasive breast ductal carcinoma

2020 ◽  
Author(s):  
Nannan Liu ◽  
Dongxue Qi ◽  
Jing Jiang ◽  
Jihong Zhang ◽  
Chunyan Yu
Keyword(s):  
Expression Pattern ◽  
Ductal Carcinoma ◽  
Invasive Breast Ductal Carcinoma

Abstract B14: Sprouty4 regulates the transition to invasive breast ductal carcinoma through ERK/MAPK signaling

2018 ◽  
Author(s):  
Ethan J. Brock ◽  
Ryan Jackson ◽  
Julie L. Boerner ◽  
Quanwen Li ◽  
Bonnie F. Sloane ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Mapk Signaling ◽  
Erk Mapk ◽  
Invasive Breast Ductal Carcinoma

The prognostic significance of infiltrating immune cells subtypes in invasive ductal carcinoma of the breast.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23177-e23177
Author(s):  
Qiuhong Zheng
Keyword(s):  
Immune Cell ◽  
Ductal Carcinoma ◽  
Primary Tumour ◽  
Prognostic Significance ◽  
Cancer Prognosis ◽  
Invasive Ductal Breast Carcinoma ◽  
Kaplan Meier ◽  
Immune Cell Subsets ◽  
The Mean ◽  
Invasive Breast Ductal Carcinoma

e23177 Background: To explore the correlation between tumour infiltrating immune cell subsets and breast cancer prognosis. Methods: Specimens of 102 patients with invasive breast ductal carcinoma were analyzed for immune -related markers (CD8, CD20, FoxP3 and CD68). The number of positive cells in 3 most highly-stained intratumoural stroma areas of the primary tumour was counted. The mean number of each marker was calculated and used to divide patients into two groups respectively (CD8high/CD8low group, CD20high/CD20low group, FOXP3high/ FOXP3 low group and CD68high/CD68 low group). Results: Kaplan–Meier survival analysis showed : (A) For all patients, high tumour-infiltrating CD8+ and CD20+ B lymphocytes , low tumour-infiltrating FoxP3+ Treg and CD68+ macrophages all increased the OS and DFS (P < 0.05); (B) For both the 35 ER negative and the 45 lymphonode negative patients, high CD8+ CTLs increased the OS and DFS(P < 0.05). Multivariate analysis of OS and DFS showed for all patients, high CD8+ CTLs and low FoxP3+ Treg were related to good OS and DFS(P < 0.05). Conclusions: high number of tumour-infiltrating CD8 and low FoxP3 T lymphocytes both could function as potential independent prognostic markers for invasive ductal breast carcinoma .

scholarly journals Mammary and Extramammary Paget’s Disease Presented Different Expression Pattern of Steroid Hormone Receptors

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Songxia Zhou ◽  
Weixiang Zhong ◽  
Ruiqin Mai ◽  
Guohong Zhang
Keyword(s):  
Expression Pattern ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Molecular Subtype ◽  
Steroid Hormone ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Steroid Hormone Receptors ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

Background and Objectives. Paget’s disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget’s disease (EMPD). Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD. Methods. Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method. Results. Positive expression of AR was significantly higher in EMPD (61.11%, 44/72) than in MPD (32.95%, 29/88) (P<0.001), while ER expression was positive 19.44% (14/72) in EMPD and only 9.09% (8/88) in MPD (P=0.059). ER-AR expression pattern was significantly different between MPD (3.41%, 3/88) and EMPD (16.67%, 12/72) (P<0.001). No difference of AR (P=0.301) or ER (P=0.239) expression was identified between invasive (48.57%, 51/105 of AR, and 11.43%, 12/105 of ER) and noninvasive PD. In MPD, no difference of AR expression between MPD alone (7/18, 38.89%) and MPD with underling ductal carcinoma of breast (22/70, 31.43%) was identified (P=0.548). In EMPD, expression of AR was 63.33% (38/60) in penoscrotal EMPD. Conclusion. Our current results indicate that MPD and EMPD presented different expression pattern of AR and ER and would help to further identify the molecular subtype of MPD and EMPD for adjuvant hormonal therapy, especially for patients with penoscrotal EMPD.

The receptor expression pattern in ductal carcinoma in situ predicts recurrence

2006 ◽  
Vol 192 (1) ◽  
pp. 68-71 ◽  
Author(s):  
Julie Kepple ◽  
Ronda S. Henry-Tillman ◽  
V. Suzanne Klimberg ◽  
Rakshanda Layeeque ◽  
Eric Siegel ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Receptor Expression

scholarly journals Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Galasso ◽  
Giorgio Costantino ◽  
Lorenzo Pasquali ◽  
Linda Minotti ◽  
Federica Baldassari ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Circular Rnas ◽  
Next Generation ◽  
Genomic Context ◽  
Functional Roles ◽  
In Situ Carcinoma ◽  
The Common ◽  
Generation Sequencing ◽  
Invasive Breast Ductal Carcinoma

The recent advantage obtained by next generation sequencing allows a depth investigation of a new “old” kind of noncoding transcript, the circular RNAs. Circular RNAs are nontranslated RNAs, typically nonpolyadenylated, with a resistance to exonucleases that gives them the ability to be more stable than the common linear RNA isoforms. We used a bioinformatic detection tool (CIRCexplorer) to research predictive circRNAs from the next generation sequenced data of five samples of ductal in situ carcinoma (DCIS) and matched adjacent invasive ductal carcinoma (IDC). Furthermore, we also investigated the circular RNAs expressed in MCF7, an invasive breast ductal carcinoma cell line. We described the genomic context of the predicted circular RNAs and we address the hypothetical possible functional roles. This study showed a perspective of a panel of predictive circRNAs identified and the function that circRNAs could exert.

Sign in / Sign up

Export Citation Format

Share Document