scholarly journals Long non‑coding RNA mortal obligate RNA transcript inhibits the migration and invasion of colon cancer cells by inactivating transforming growth factor β1

2019 ◽  
Author(s):  
Taicheng Zhou ◽  
Lili Wu ◽  
Zhen Zong ◽  
Ning Ma ◽  
Yingru Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Transcript

scholarly journals The significance of homeodomain transcription factor 2 in colon cancer cells

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yang He ◽  
Peng Gong ◽  
Sitong Wang ◽  
Qing Xu ◽  
Jianhua Chen
Keyword(s):  
Cervical Cancer ◽  
Colon Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Homeodomain Transcription Factor ◽  
Non Coding Rna ◽  
Related Proteins ◽  
Long Non Coding Rna

Abstract Background Colon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the progression of several types of cancer via regulating the Wnt/β-catenin pathway. It has also been demonstrated that high levels of long non-coding RNA (lncRNA) gastric carcinoma high expressed transcript 1 (GHET1) can also promote the development of cervical cancer via activating the Wnt/β-catenin pathway. However, whether PITX2 can affect the development of colon cancer via regulating the expression of lncRNA GHET1 remains unclear. Results The results demonstrated that PITX2 knockdown attenuated the proliferation, migration and invasion abilities of colon cancer cells. Additionally, PITX2 promoted the expression of lncRNA GHET1 via binding to its promoter. Overexpression of lncRNA GHET1 induced the expression of Wnt/β-catenin signaling-related proteins, cyclin D1, c-Myc and MMP-7. Furthermore, lncRNA GHET1 overexpression abrogated the PITX2 silencing-mediated decreased proliferation, migration and invasion abilities of colon cancer cells. Conclusion The findings of the present study suggested that PITX2 could enhance the proliferation, migration and invasion abilities of colon cancer cells via upregulating lncRNA GHET1 and activating the Wnt/β-catenin pathway.

scholarly journals LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Shicai Ye ◽  
Bilan Sun ◽  
Weiyun Wu ◽  
Caiyuan Yu ◽  
Ting Tian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Colon Adenocarcinoma ◽  
Colon Cancer Cells ◽  
Prognostic Signature ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Colon Cancer Progression ◽  
Long Non Coding Rna

Abstract Colon cancer is one of the major causes of cancer-related deaths worldwide. Long non-coding RNA (lncRNA) LINC01123 has been suggested to act as an oncogene in non-small cell lung cancer and a prognostic signature in head and neck squamous cell carcinoma. However, its role in colon cancer remains obscure. From TCGA database, LINC01123 was observed to be up-regulated in colon adenocarcinoma (COAD). Subsequently, the up-regulated LINC01123 was also detected in colon cancer cells. Functionally, LINC01123 could enhance cell proliferation, migration, invasion and angiogenesis. Moreover, the chemoresistance of colon cancer cells was verified to be promoted by LINC01123. Afterward, LINC01123 was found to bind with Ago2 and miR-34c-5p. Besides, miR-34c-5p was confirmed to inhibit the cellular process and chemoresistance of colon cancer cells. Then, VEGFA was disclosed to coexist with LINC01123 and miR-34c-5p in RNA-induced silencing complex. And TCGA database suggested that its expression was correlated with different stages of COAD. Moreover, it was uncovered that VEGFA could bind with miR-34c-5p and its expression positively correlated with LINC01123 expression. Finally, LINC01123 was proofed to regulate colon cancer progression and cells chemoresistance via VEGFA. In conclusion, LINC01123/miR-34c-5p/VEGFA axis promotes colon cancer malignancy and cells chemoresistance.

Expression of long non-coding RNA LINC00973 is consistently increased upon treatment of colon cancer cells with different chemotherapeutic drugs

Biochimie ◽  
2018 ◽  
Vol 151 ◽  
pp. 67-72 ◽  
Author(s):  
Olga L. Zinovieva ◽  
Evgenia N. Grineva ◽  
Maria M. Prokofjeva ◽  
Dmitry S. Karpov ◽  
Andrei O. Zheltukhin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Chemotherapeutic Drugs ◽  
Colon Cancer Cells ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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