scholarly journals NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF‑κB signaling pathways

2019 ◽  
Author(s):  
Fei Ren ◽  
Wei Zhang ◽  
Shuai Lu ◽  
Hong Ren ◽  
Yantong Guo
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Abstract 1468: MTA2 enhances breast cancer metastasis via regulation of the cytoskeleton and rho signaling pathways

2011 ◽  
Author(s):  
Kyle R. Covington ◽  
Lauren Brusco ◽  
Amanda Beyer ◽  
Weiyan Cai ◽  
Arnoldo Corona-Rodriguez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Abstract B092: Beta-blockade of breast cancer metastasis: Receptor regulation and downstream signaling pathways

2013 ◽  
Author(s):  
Ming Gene Chai ◽  
Caroline P. Le ◽  
Sarah J. Creed ◽  
Benjamin A L Finnin ◽  
Matthew A. Pimentel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Receptor Regulation ◽  
Beta Blockade ◽  
Downstream Signaling

Denbinobin suppresses breast cancer metastasis through the inhibition of Src-mediated signaling pathways

2011 ◽  
Vol 22 (8) ◽  
pp. 732-740 ◽  
Author(s):  
Pei-Hsuan Chen ◽  
Chieh-Yu Peng ◽  
Hui-Chen Pai ◽  
Che-Ming Teng ◽  
Chien-Chih Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

scholarly journals TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-κB signaling pathways

Oncotarget ◽  
2017 ◽  
Vol 8 (30) ◽  
pp. 48889-48904 ◽  
Author(s):  
Kaili Lian ◽  
Chao Ma ◽  
Chunyan Hao ◽  
Yan Li ◽  
Na Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis

Regulation of Runx2 and its signaling pathways by microRNAs in breast cancer metastasis

2020 ◽  
Vol 21 ◽  
Author(s):  
Shivashankar Pranavkrishna ◽  
Ganesh Sanjeev ◽  
Ravishkumar L. Akshaya ◽  
Muthukumar Rohini ◽  
Nagarajan Selvamurugan
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Signaling Pathways ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Primary Research ◽  
Research Focus ◽  
Runx2 Expression ◽  
Major Threat

: Posing as a major threat among women globally, breast cancer (BC) emerges as a primary research focus for several researchers. Although various therapeutic regimens are available, there is an increased chance of metastasis of BC cells, which raises the severity of this malignancy. Of multiple preferred secondary targets, metastasis to bone is extensively studied. Besides deemed as a bone transcription factor, Runx2 also acts as a metastatic factor that promotes growth and metastasis of BC cells. Studies have reported the significant role of microRNAs (miRNAs) in BC pathogenesis and metastasis by governing Runx2 expression. Additionally, dysregulation of the signaling pathways, including Wnt/β-catenin, TGF-β, Notch, and PI3K/AKT, have been observed to influence the expression of Runx2 in BC cells. In this review, we have aimed to highlight the regulatory role of miRNAs in targeting Runx2 both directly and indirectly by governing respective signaling pathways during bone metastasis of BC.

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