scholarly journals Long non‑coding RNA heart and neural crest derivatives expressed�2‑antisense RNA�1 overexpression inhibits the proliferation of cancer cells by reducing RUNX2 expression in triple‑negative breast cancer

2019 ◽  
Author(s):  
Min Wei ◽  
Lei Liu ◽  
Zhiwei Wang
Keyword(s):  
Breast Cancer ◽  
Neural Crest ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Antisense Rna ◽  
Triple Negative ◽  
Runx2 Expression ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO

2020 ◽  
Vol 52 (8) ◽  
pp. 801-809 ◽  
Author(s):  
Jinghua Chen ◽  
Meiqin Zhu ◽  
Liqiu Zou ◽  
Junxian Xia ◽  
Jiacheng Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract The treatment of triple-negative breast cancer (TNBC) relies largely on chemotherapies. However, it is frequent that TNBC patients develop resistance to the chemotherapy drugs. Generation of drug-resistant cell lines facilitates the identification of drug resistance. Here, we established two paclitaxel (PTX)-resistant TNBC cancer cell lines using an intermittent and stepwise method and found that long non-coding RNA long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) was significantly decreased in PTX-resistant cancer cells. Ectopic expression of LINC-PINT sensitized both PTX-resistant TNBC and wild-type TNBC to PTX. Moreover, RNA immunoprecipitation showed that LINC-PINT bound to RNA-binding protein NONO. Overexpression of LINC-PINT resulted in the degradation of NONO in a proteasome-dependent manner and vice versa. Knockdown of NONO with siRNA sensitized TNBC to PTX. We further analyzed the expression level of LINC-PINT and NONO in patient samples via online database and found that LINC-PINT and NONO may function antagonistically in all types of breast cancers. Taken together, our data illustrated a tumor suppressor role of LINC-PINT in sensitizing TNBC to chemotherapies via destabilizing NONO.

scholarly journals The long non-coding RNA ADAMTS9-AS2 was identified as a potential prognostic biomarker in triple-negative breast cancer

2020 ◽  
Vol 6 (3) ◽  
pp. 16215-16226
Author(s):  
Daniel Rodrigues Bastos ◽  
Jean Michel Rocha Sampaio Leite ◽  
Mércia Patrícia Ferreira Conceição ◽  
Cesar Augusto Sam Tiago Vilanova-Costa ◽  
Antonio Márcio Teodoro Cordeiro Silva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Prognostic Biomarker ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals EPHA2 antisense RNA modulates EPHA2 mRNA levels in basal-like/triple-negative breast cancer cells

Biochimie ◽  
2020 ◽  
Vol 179 ◽  
pp. 169-180
Author(s):  
Tetsuya Okuyama ◽  
Ryou Sakamoto ◽  
Kazuhiro Kumagai ◽  
Mikio Nishizawa ◽  
Tomonori Kimura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Antisense Rna ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Mrna Levels

Long non-coding RNA TUG1 sponges miR-197 to enhance cisplatin sensitivity in triple negative breast cancer

2018 ◽  
Vol 107 ◽  
pp. 338-346 ◽  
Author(s):  
Tielei Tang ◽  
Yonggang Cheng ◽  
Qing She ◽  
Yaru Jiang ◽  
Yuanyuan Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Non Coding Rna ◽  
Cisplatin Sensitivity ◽  
Long Non Coding Rna
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