scholarly journals Dauricine suppresses the growth of pancreatic cancer in�vivo by modulating the Hedgehog signaling pathway

2019 ◽  
Author(s):  
Ying‑Bo Zhang ◽  
Hong‑Xin Fei ◽  
Jia Guo ◽  
Xiao‑Jie Zhang ◽  
Shu‑Liang Wu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway

scholarly journals The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Ming Ji ◽  
Zhihui Zhang ◽  
Songwen Lin ◽  
Chunyang Wang ◽  
Jing Jin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Kinase Inhibitor ◽  
Therapeutic Option ◽  
Hedgehog Signaling Pathway ◽  
Orthotopic Mouse Model ◽  
Cycle Arrest ◽  
The Central Nervous System

Glioblastoma multiforme (GBM) is the most common malignant tumor of the central nervous system. Temozolomide (TMZ)–based adjuvant treatment has improved overall survival, but clinical outcomes remain poor; TMZ resistance is one of the main reasons for this. Here, we report a new phosphatidylinositide 3-kinase inhibitor, XH30; this study aimed to assess the antitumor activity of this compound against TMZ-resistant GBM. XH30 inhibited cell proliferation in TMZ-resistant GBM cells (U251/TMZ and T98G) and induced cell cycle arrest in the G1 phase. In an orthotopic mouse model, XH30 suppressed TMZ-resistant tumor growth. XH30 was also shown to enhance TMZ cytotoxicity both in vitro and in vivo. Mechanistically, the synergistic effect of XH30 may be attributed to its repression of the key transcription factor GLI1 via the noncanonical hedgehog signaling pathway. XH30 reversed sonic hedgehog–triggered GLI1 activation and decreased GLI1 activation by insulin-like growth factor 1 via the noncanonical hedgehog signaling pathway. These results indicate that XH30 may represent a novel therapeutic option for TMZ-resistant GBM.

Resveratrol Inhibits Proliferation and Induces Apoptosis through the Hedgehog Signaling Pathway in Pancreatic Cancer Cell

Pancreatology ◽  
2011 ◽  
Vol 11 (6) ◽  
pp. 601-609 ◽  
Author(s):  
Wenhui Mo ◽  
Xuanfu Xu ◽  
Ling Xu ◽  
Feng Wang ◽  
Aiwu Ke ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Hedgehog Signaling ◽  
Pancreatic Cancer Cell ◽  
Hedgehog Signaling Pathway

scholarly journals Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells

2007 ◽  
Vol 282 (19) ◽  
pp. 14048-14055 ◽  
Author(s):  
Zhenyu Ji ◽  
Fang C. Mei ◽  
Jingwu Xie ◽  
Xiaodong Cheng
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Pancreatic Cancer Cells

Importance of hedgehog signaling pathway in pancreatic cancer treatment and prognosis

Pancreatology ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. S37
Author(s):  
Beatrice Mohelnikova-Duchonova ◽  
Martin Kocik ◽  
Barbara Duchonova ◽  
Veronika Brynychova ◽  
Martin Oliverius ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Treatment ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway
Sign in / Sign up

Export Citation Format

Share Document