scholarly journals Original tumour suppressor gene polycystic kidney and hepatic disease 1‑like 1 is associated with thyroid cancer cell progression

2019 ◽  
Author(s):  
Chen Zheng ◽  
Ruida Quan ◽  
Er‑Jie Xia ◽  
Adheesh Bhandari ◽  
Xiaohua Zhang
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Hepatic Disease ◽  
Tumour Suppressor ◽  
Thyroid Cancer Cell ◽  
Polycystic Kidney ◽  
Original Tumour ◽  
Cell Progression

170 PATZ1 is a New Candidate Tumour-suppressor Gene in Thyroid Cancer

2012 ◽  
Vol 48 ◽  
pp. S41
Author(s):  
T. Valentino ◽  
M. Vitiello ◽  
R. Pasquinelli ◽  
D. Palmieri ◽  
M. Monaco ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Candidate Tumour Suppressor

scholarly journals The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein

2020 ◽  
Vol 21 (3) ◽  
pp. 702
Author(s):  
Raffaela Mariarosaria Mariniello ◽  
Francesca Maria Orlandella ◽  
Anna Elisa De Stefano ◽  
Paola Lucia Chiara Iervolino ◽  
Giovanni Smaldone ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Biological Effects ◽  
Tumour Suppressor ◽  
Human Thyroid ◽  
Migration And Invasion ◽  
Thyroid Cancer Cell ◽  
Thyroid Cancer Cells

Thyroid carcinoma is the most common endocrine cancer and includes different forms. Among these, anaplastic thyroid carcinoma (ATC) is the rarest but the most lethal subtype, compared to papillary thyroid carcinoma (PTC) which shows an overall good prognosis. We have previously showed that Tumor Suppressor Candidate 2 (TUSC2), a known tumour suppressor gene, is downregulated in human PTC and ATC compared to normal thyroid samples. The aim of this study was to gain insight into the molecular mechanisms induced by TUSC2 in thyroid cancer cells. Here, we stably transfected TUSC2 in papillary (TPC-1) and in anaplastic (8505C) thyroid cancer cell lines and studied its effects on several biological processes, demonstrating that TUSC2 overexpression decreased thyroid cancer cell proliferation, migration and invasion. Through the proteome profiler apoptosis array, we observed that TUSC2 increased sensitivity to apoptosis by increasing the SMAC/DIABLO and CYTOCHROME C proteins. On the other hand, transient silencing of TUSC2, by siRNA, in an immortalized thyroid follicular epithelial cell line (Nthy-ori 3-1) showed the opposite effect. Finally modulation of SMAC/DIABLO partially rescued the biological effects of TUSC2. Thus, our data highlight a tumour suppressor role of TUSC2 in thyroid carcinogenesis, suggesting that it could be a promising target and biomarker for thyroid carcinoma.

scholarly journals Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yunchao Xin ◽  
Xiaoling Shang ◽  
Xiaoran Sun ◽  
Yachao Liu ◽  
Guogang Xu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Motility ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Thyroid Cancer Cell ◽  
Trefoil Factor ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Trefoil Factor 3 ◽  
Cell Progression

Objectives. Abnormal expression of trefoil factor 3 (TFF3) in breast, stomach, and colon tumors may be related to the occurrence of tumors, suggesting its role in angiogenesis. In this study, the aim was to explore the role of TFF3 in thyroid cancer. Methods. TFF3 expression analysis was performed via GEPIA and RT-PCR. To explore the effects of TFF3 on thyroid cancer cell motility, cell function assays were performed. Furthermore, GSEA pathway analysis and western blot were used to explore the mechanism by which TFF3 represses the progression of thyroid cancer cells. Results. Here, we showed that low expression level of TFF3 in thyroid cancer is related to thyroid cancer nodal metastasis. The patients with low TFF3 expression showed worse disease-free survival than those with high level of TFF3. Underexpressed TFF3 increased cell motility and inhibited cell apoptosis. We found that the levels of IL-6, p-JAK2/JAK2, and pSTAT3/STAT3 were inhibited in the pcDNA-TFF3 group compared to the pcDNA-NC group and these factors were upregulated in the si-TFF3 group compared to the si-NC group in BCPAP and TPC-1 cells. Conclusion. TFF3 inhibits thyroid cancer cell progression related to IL-6/JAK/STAT3 signaling pathway.

tumour suppressor gene and the tobacco industry

The Lancet ◽  
2005 ◽  
Vol 365 (9464) ◽  
pp. 1026-1027
Author(s):  
A BITTON ◽  
M NEUMAN ◽  
J BARNOYA ◽  
S GLANTZ
Keyword(s):  
Tobacco Industry ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor

Influence of AUF1 targeting siRNA on cell cycle-related proteins in thyroid cancer cell lines

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
B Trojanowicz ◽  
Z Chen ◽  
J Bialek ◽  
Y Radestock ◽  
S Hombach-Klonisch ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Thyroid Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Thyroid Cancer Cell ◽  
Thyroid Cancer Cell Lines ◽  
Related Proteins
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